Head to Head
| England Premier League 2 | 2025/01/24 19:00 | Chelsea U21 v Southampton U21 | L | 0-2 |
| England Premier League 2 | 2024/04/26 18:00 | Chelsea U21 v Southampton U21 | W | 2-0 |
Home History
| England Premier League 2 | 2025/11/08 14:00 | Chelsea U21 v Reading U21 | W | 4-1 |
| England Premier League 2 | 2025/10/31 19:00 | Everton U21 v Chelsea U21 | L | 1-0 |
| England EFL Trophy | 2025/10/28 19:00 | Walsall v Chelsea U21 | L | 4-2 |
| England Premier League 2 | 2025/10/25 13:00 | Chelsea U21 v Arsenal U21 | W | 2-1 |
| Premier League International Cup | 2025/10/18 13:00 | Chelsea U21 v Dinamo Zagreb U21 | L | 1-2 |
| England Premier League 2 | 2025/10/05 11:00 | Burnley U21 v Chelsea U21 | W | 0-1 |
| England Premier League 2 | 2025/09/27 10:00 | Chelsea U21 v Stoke U21 | L | 1-2 |
| England EFL Trophy | 2025/09/23 18:00 | Northampton v Chelsea U21 | L | 3-0 |
Away History
| England Premier League 2 | 2025/11/07 19:00 | Southampton U21 v Arsenal U21 | D | 1-1 |
| England Premier League 2 | 2025/11/01 13:30 | Tottenham U21 v Southampton U21 | W | 1-2 |
| Premier League International Cup | 2025/10/29 19:00 | Southampton U21 v Real Madrid U21 | D | 1-1 |
| England Premier League 2 | 2025/10/25 12:00 | Leicester U21 v Southampton U21 | L | 3-1 |
| England National League Cup | 2025/10/21 18:00 | Aldershot v Southampton U21 | W | 5-7 |
| England Premier League 2 | 2025/10/03 18:00 | Southampton U21 v Derby U21 | W | 4-1 |
| England Premier League 2 | 2025/09/26 18:00 | Man City U21 v Southampton U21 | D | 3-3 |
| England Premier League 2 | 2025/09/19 18:00 | Southampton U21 v Burnley U21 | W | 2-1 |