| Colombia Regional League | 2025/03/15 21:16 | Color Esperanza v Medellin City FC | D | 3-3 |
| Colombia Regional League | 2025/07/28 15:00 | FC Leones Reserves v Medellin City FC | L | 2-0 |
| Colombia Regional League | 2025/07/22 17:30 | Atletico Nacional Medellin Reserves v Medellin City FC | L | 2-0 |
| Colombia Regional League | 2025/07/16 15:00 | Medellin City FC v CD Ciclos | L | 4-5 |
| Colombia Regional League | 2025/07/05 21:10 | Belen Arco Zaragoza v Medellin City FC | L | 2-0 |
| Colombia Regional League | 2025/06/16 14:13 | Ferrovalvulas FC v Medellin City FC | D | 4-4 |
| Colombia Regional League | 2025/06/01 21:00 | Medellin City FC v Tiendas Margos | L | 1-4 |
| Colombia Regional League | 2025/04/26 19:17 | Medellin City FC v Sol de Oriente | L | 0-2 |
| Colombia Regional League | 2025/04/12 01:10 | Politecnico J.I.C. v Medellin City FC | W | 1-4 |
| Colombia Regional League | 2025/07/12 21:18 | Color Esperanza v Tiendas Margos | L | 2-3 |
| Colombia Regional League | 2025/07/08 17:00 | Envigado FC Reserves v Color Esperanza | W | 0-1 |
| Colombia Regional League | 2025/06/28 21:21 | Color Esperanza v Molino Viejo | L | 1-2 |
| Colombia Regional League | 2025/06/02 16:10 | Color Esperanza v Sol de Oriente | W | 6-3 |
| Colombia Regional League | 2025/04/26 21:25 | Color Esperanza v Aguilas Doradas Reserves | D | 1-1 |
| Colombia Regional League | 2025/04/12 21:10 | Color Esperanza v FC Leones Reserves | W | 3-2 |
| Colombia Regional League | 2025/03/15 21:16 | Color Esperanza v Medellin City FC | D | 3-3 |
| Colombia Regional League | 2025/03/01 21:32 | Color Esperanza v CD Ciclos | L | 1-3 |