Stadium: Seaverns Field at Harold Alfond Stadium Round: 1
| NCAAF | 2024/10/12 17:00 | Wesleyan Cardinals v Colby Mules | L | 23-17 |
| NCAAF | 2023/10/07 17:00 | Colby Mules v Wesleyan Cardinals | W | 20-13 |
| NCAAF | 2022/10/08 17:00 | Wesleyan Cardinals v Colby Mules | L | 31-14 |
| NCAAF | 2021/09/18 17:00 | Colby Mules v Wesleyan Cardinals | L | 5-21 |
| NCAAF | 2019/09/14 17:00 | Wesleyan Cardinals v Colby Mules | L | 30-10 |
| NCAAF | 2018/10/06 17:00 | Colby Mules v Wesleyan Cardinals | L | 20-28 |
| NCAAF | 2024/11/09 22:00 | Bowdoin Polar Bears v Colby Mules | W | 10-34 |
| NCAAF | 2024/11/02 17:00 | Colby Mules v Tufts Jumbos | L | 21-28 |
| NCAAF | 2024/10/26 16:00 | Hamilton Continentals v Colby Mules | W | 13-16 |
| NCAAF | 2024/10/19 17:00 | Colby Mules v Amherst Mammoths | W | 38-7 |
| NCAAF | 2024/10/12 17:00 | Wesleyan Cardinals v Colby Mules | L | 23-17 |
| NCAAF | 2024/10/05 23:00 | Colby Mules v Bates Bobcats | W | 28-26 |
| NCAAF | 2024/09/28 17:00 | Middlebury Panthers v Colby Mules | L | 24-16 |
| NCAAF | 2024/09/21 17:00 | Colby Mules v Williams Ephs | L | 19-24 |
| NCAAF | 2024/11/09 17:00 | Trinity Bantams v Wesleyan Cardinals | W | 17-27 |
| NCAAF | 2024/11/02 17:00 | Wesleyan Cardinals v Williams Ephs | W | 25-24 |
| NCAAF | 2024/10/26 17:00 | Amherst Mammoths v Wesleyan Cardinals | W | 14-31 |
| NCAAF | 2024/10/19 17:00 | Bowdoin Polar Bears v Wesleyan Cardinals | W | 14-17 |
| NCAAF | 2024/10/12 17:00 | Wesleyan Cardinals v Colby Mules | W | 23-17 |
| NCAAF | 2024/10/05 17:00 | Hamilton Continentals v Wesleyan Cardinals | W | 7-19 |
| NCAAF | 2024/09/28 17:00 | Wesleyan Cardinals v Bates Bobcats | L | 13-24 |
| NCAAF | 2024/09/21 23:00 | Wesleyan Cardinals v Tufts Jumbos | W | 20-9 |