[14] 2BC 3-2 OTT Senators [17] 2025-11-08 04:00
Stadium: Canadian Tire Centre
Home Manager: Lindy Ruff Away Manager: Travis Green
Head to Head
| NHL | 2025/10/15 23:00 | OTT Senators v BUF Sabres | W | 4-8 |
| NHL | 2025/04/01 23:00 | BUF Sabres v OTT Senators | W | 5-2 |
| NHL | 2025/03/25 23:00 | OTT Senators v BUF Sabres | W | 2-3 |
| NHL | 2025/01/10 00:00 | BUF Sabres v OTT Senators | W | 4-0 |
| NHL | 2024/11/06 00:00 | OTT Senators v BUF Sabres | W | 1-5 |
| NHL Pre-Season | 2024/09/26 23:00 | BUF Sabres v OTT Senators | W | 3-2 |
| NHL | 2024/03/27 23:00 | OTT Senators v BUF Sabres | L | 6-2 |
| NHL | 2024/01/12 00:00 | OTT Senators v BUF Sabres | W | 3-5 |
Home History
| NHL | 2025/11/07 00:00 | STL Blues v BUF Sabres | L | 3-0 |
| NHL | 2025/11/05 00:00 | UTA Mammoth v BUF Sabres | L | 2-1 |
| NHL | 2025/11/01 23:00 | WAS Capitals v BUF Sabres | W | 3-4 |
| NHL | 2025/10/30 23:00 | BUF Sabres v BOS Bruins | L | 3-4 |
| NHL | 2025/10/28 22:45 | CLB Blue Jackets v BUF Sabres | L | 4-3 |
| NHL | 2025/10/25 21:00 | BUF Sabres v TOR Maple Leafs | L | 3-4 |
| NHL | 2025/10/24 23:00 | TOR Maple Leafs v BUF Sabres | W | 3-5 |
| NHL | 2025/10/22 23:30 | DET Red Wings v BUF Sabres | W | 2-4 |
Away History
| NHL | 2025/11/07 00:00 | OTT Senators v BOS Bruins | L | 2-3 |
| NHL | 2025/11/01 23:00 | OTT Senators v MTL Canadiens | L | 3-4 |
| NHL | 2025/10/30 23:00 | CGY Flames v OTT Senators | W | 3-4 |
| NHL | 2025/10/29 00:45 | OTT Senators v CHI Blackhawks | L | 3-7 |
| NHL | 2025/10/27 23:30 | BOS Bruins v OTT Senators | W | 2-7 |
| NHL | 2025/10/25 23:00 | OTT Senators v WAS Capitals | W | 7-1 |
| NHL | 2025/10/23 23:00 | PHI Flyers v OTT Senators | W | 1-2 |
| NHL | 2025/10/21 23:00 | EDM Oilers v OTT Senators | L | 3-2 |