[5] Tigres UANL 2-1 Santos Laguna [7] 2018-09-22 17:00
Stadium: Estadio Universitario (UANL) Round: 5
Referee: Erick Yair Miranda Galindo Home Manager: Ricardo Ferretti Away Manager: Salvador Reyes
Head to Head
| Mexico Liga MX | 2018/08/19 23:00 | Santos Laguna v Tigres UANL | L | 3-1 |
| Mexico Champion of Champions | 2018/07/16 01:00 | Tigres UANL v Santos Laguna | W | 4-0 |
| Mexico Liga MX | 2018/05/06 23:00 | Santos Laguna v Tigres UANL | L | 2-0 |
| Mexico Liga MX | 2018/05/04 00:30 | Tigres UANL v Santos Laguna | W | 2-0 |
| Mexico Liga MX | 2018/01/14 01:00 | Tigres UANL v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2017/07/30 23:30 | Santos Laguna v Tigres UANL | D | 1-1 |
| Mexico Liga MX | 2017/01/08 01:00 | Tigres UANL v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2016/07/17 23:00 | Santos Laguna v Tigres UANL | D | 0-0 |
Home History
| Campeones Cup | 2018/09/20 00:40 | Toronto FC v Tigres UANL | W | 1-3 |
| Mexico Liga MX | 2018/09/16 00:00 | Pachuca v Tigres UANL | D | 1-1 |
| Mexico Liga MX | 2018/09/02 00:00 | Tigres UANL v Atlas | W | 3-1 |
| Mexico Cup | 2018/08/30 00:00 | Cafetaleros de Tapachula FC v Tigres UANL | W | 0-1 |
| Mexico Liga MX | 2018/08/26 02:00 | Necaxa v Tigres UANL | D | 1-1 |
| Mexico Liga MX | 2018/08/23 02:00 | Tigres UANL v Veracruz | W | 4-0 |
| Mexico Liga MX | 2018/08/19 23:00 | Santos Laguna v Tigres UANL | L | 3-1 |
| Mexico Cup | 2018/08/16 02:00 | Tigres UANL v Atletico San Luis | W | 5-1 |
Away History
| Mexico Liga MX | 2018/09/16 21:00 | Santos Laguna v Leon | W | 3-0 |
| World Club Friendlies | 2018/09/05 23:41 | Charlotte Independence v Santos Laguna | W | 0-3 |
| Mexico Liga MX | 2018/09/02 17:00 | Toluca v Santos Laguna | L | 2-1 |
| Mexico Cup | 2018/08/30 00:00 | Santos Laguna v Pachuca | D | 0-0 |
| Mexico Liga MX | 2018/08/26 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Mexico Liga MX | 2018/08/23 02:06 | Tijuana v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2018/08/19 23:00 | Santos Laguna v Tigres UANL | W | 3-1 |
| Mexico Cup | 2018/08/16 00:00 | Club Celaya v Santos Laguna | L | 2-0 |