[61] Lucie Safarova 3-6,4-6 Serena Williams [2] 2016-12-05 08:30
Stadium: ROD LAVER ARENA Round: 24 Ground: Hardcourt outdoor
Head to Head
| Hopman Cup Women | 2015/01/08 09:30 | Lucie Safarova v Serena Williams | 3-6,7-6,6-7 |
| WTA Montreal | 2014/08/07 20:00 | Serena Williams v Lucie Safarova | 7-5,6-4 |
Home History
| WTA Moscow | 2016/10/18 10:00 | Lucie Safarova v Daria Saville | 2-6,2-6 |
| WTA Beijing | 2016/10/03 04:30 | Karolina Pliskova v Lucie Safarova | 6-7,6-1,6-4 |
| WTA Wuhan | 2016/09/26 12:40 | Karolina Pliskova v Lucie Safarova | 6-3,7-5 |
| WTA Wuhan | 2016/09/25 06:00 | Varvara Lepchenko v Lucie Safarova | 5-7,3-6 |
| WTA Tokyo | 2016/09/20 03:35 | Lucie Safarova v Dominika Cibulkova | 6-4,1-6,5-7 |
| US Open 2016 Women | 2016/09/01 15:00 | Lucie Safarova v Simona Halep | 3-6,4-6 |
| US Open 2016 Women | 2016/08/30 15:00 | Lucie Safarova v Daria Saville | 6-4,6-4 |
| WTA Montreal | 2016/07/26 19:00 | Lucie Safarova v Eugenie Bouchard | 3-6,6-3,6-7 |
Away History
| US Open 2016 Women | 2016/09/08 23:00 | Serena Williams v Karolina Pliskova | 2-6,6-7 |
| US Open 2016 Women | 2016/09/07 23:00 | Serena Williams v Simona Halep | 6-2,4-6,6-3 |
| US Open 2016 Women | 2016/09/05 19:45 | Serena Williams v Yaroslava Shvedova | 6-2,6-3 |
| US Open 2016 Women | 2016/09/03 17:35 | Serena Williams v Johanna Larsson | 6-2,6-1 |
| US Open 2016 Women | 2016/09/01 23:00 | Serena Williams v Vania King | 6-3,6-3 |
| US Open 2016 Women | 2016/08/30 23:00 | Serena Williams v Ekaterina Makarova | 6-3,6-3 |
| Wimbledon Women | 2016/07/09 13:00 | Serena Williams v Angelique Kerber | 7-5,6-3 |
| Wimbledon Women | 2016/07/07 12:00 | Serena Williams v Elena Vesnina | 6-2,6-0 |