[9] John Isner 4-6,6-7 Karen Khachanov [13] 2018-12-06 19:10
Stadium: Stadium 2 Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP Paris | 2018/11/01 12:00 | Karen Khachanov v John Isner | 6-4,6-7,7-6 |
| ATP Toronto | 2018/08/09 22:40 | Karen Khachanov v John Isner | 7-6,7-6 |
| French Open | 2017/06/03 14:15 | John Isner v Karen Khachanov | 6-7,3-6,7-6,6-7 |
Home History
| ATP World Tour Finals | 2018/11/16 14:00 | Alexander Zverev v John Isner | 7-6,6-3 |
| ATP World Tour Finals | 2018/11/14 20:00 | Marin Cilic v John Isner | 6-7,6-3,6-4 |
| ATP World Tour Finals | 2018/11/12 20:00 | Novak Djokovic v John Isner | 6-4,6-3 |
| ATP Paris | 2018/11/01 12:00 | Karen Khachanov v John Isner | 6-4,6-7,7-6 |
| ATP Paris | 2018/10/31 10:00 | Mikhail Kukushkin v John Isner | 3-6,7-6,6-7 |
| ATP Vienna | 2018/10/25 17:00 | Gael Monfils v John Isner | 6-4,6-4 |
| ATP Vienna | 2018/10/23 13:30 | Cameron Norrie v John Isner | 7-6,4-6,6-7 |
| ATP Stockholm | 2018/10/20 13:00 | John Isner v Ernests Gulbis | 6-1,3-6,3-6 |
Away History
| ATP Paris | 2018/11/04 14:00 | Karen Khachanov v Novak Djokovic | 7-5,6-4 |
| ATP Paris | 2018/11/03 13:00 | Dominic Thiem v Karen Khachanov | 4-6,1-6 |
| ATP Paris | 2018/11/02 13:00 | Alexander Zverev v Karen Khachanov | 1-6,2-6 |
| ATP Paris | 2018/11/01 12:00 | Karen Khachanov v John Isner | 6-4,6-7,7-6 |
| ATP Paris | 2018/10/29 10:00 | Karen Khachanov v Filip Krajinovic | 7-5,6-2 |
| ATP Vienna | 2018/10/25 11:00 | Karen Khachanov v Kei Nishikori | 2-6,2-6 |
| ATP Vienna | 2018/10/24 13:10 | Karen Khachanov v Dennis Novak | 6-3,7-5 |
| ATP Moscow | 2018/10/21 13:00 | Adrian Mannarino v Karen Khachanov | 2-6,2-6 |