Head to Head
| NCAAF | 2010/10/09 12:00 | Southern Mississippi v East Carolina | W | 43-44 |
| NCAAF | 2009/11/28 12:00 | East Carolina v Southern Mississippi | W | 25-20 |
| NCAAF | 2008/11/15 12:00 | Southern Mississippi v East Carolina | L | 21-3 |
| NCAAF | 2007/09/15 12:00 | East Carolina v Southern Mississippi | L | 21-28 |
| NCAAF | 2006/10/28 12:00 | Southern Mississippi v East Carolina | W | 17-20 |
| NCAAF | 2005/10/01 12:00 | East Carolina v Southern Mississippi | L | 7-33 |
| NCAAF | 2004/10/23 12:00 | Southern Mississippi v East Carolina | L | 51-10 |
| NCAAF | 2003/11/29 12:00 | East Carolina v Southern Mississippi | L | 21-38 |
Home History
| NCAAF | 2010/11/26 12:00 | East Carolina v SMU | L | 38-45 |
| NCAAF | 2010/11/20 12:00 | Rice v East Carolina | L | 62-38 |
| NCAAF | 2010/11/11 12:00 | UAB v East Carolina | W | 42-54 |
| NCAAF | 2010/11/06 12:00 | East Carolina v Navy | L | 35-76 |
| NCAAF | 2010/10/30 12:00 | Central Florida v East Carolina | L | 49-35 |
| NCAAF | 2010/10/23 12:00 | East Carolina v Marshall | W | 37-10 |
| NCAAF | 2010/10/16 12:00 | East Carolina v NC State | W | 33-27 |
| NCAAF | 2010/10/09 12:00 | Southern Mississippi v East Carolina | W | 43-44 |
Away History
| NCAAF | 2010/11/26 12:00 | Tulsa v Southern Mississippi | L | 56-50 |
| NCAAF | 2010/11/20 12:00 | Southern Mississippi v Houston | W | 59-41 |
| NCAAF | 2010/11/13 12:00 | Central Florida v Southern Mississippi | W | 21-31 |
| NCAAF | 2010/11/06 12:00 | Tulane v Southern Mississippi | W | 30-46 |
| NCAAF | 2010/10/30 12:00 | Southern Mississippi v UAB | L | 49-50 |
| NCAAF | 2010/10/16 12:00 | Memphis v Southern Mississippi | W | 19-41 |
| NCAAF | 2010/10/09 12:00 | Southern Mississippi v East Carolina | L | 43-44 |
| NCAAF | 2010/10/02 12:00 | Southern Mississippi v Marshall | W | 41-16 |