Home History
| NCAAF | 2000/11/18 12:00 | Duke v North Carolina | L | 21-59 |
| NCAAF | 2000/11/11 12:00 | NC State v Duke | L | 35-31 |
| NCAAF | 2000/11/04 12:00 | Wake Forest v Duke | L | 28-26 |
| NCAAF | 2000/10/28 12:00 | Duke v Maryland | L | 9-20 |
| NCAAF | 2000/10/21 12:00 | Georgia Tech v Duke | L | 45-10 |
| NCAAF | 2000/10/14 12:00 | Florida State v Duke | L | 63-14 |
| NCAAF | 2000/09/30 12:00 | Duke v Clemson | L | 22-52 |
| NCAAF | 2000/09/23 12:00 | Vanderbilt v Duke | L | 26-7 |
Away History
| NCAAF | 2000/11/25 12:00 | NC State v Wake Forest | L | 32-14 |
| NCAAF | 2000/11/18 12:00 | Navy v Wake Forest | W | 26-49 |
| NCAAF | 2000/11/11 12:00 | Wake Forest v Florida State | L | 6-35 |
| NCAAF | 2000/11/04 12:00 | Wake Forest v Duke | W | 28-26 |
| NCAAF | 2000/10/21 12:00 | Maryland v Wake Forest | L | 37-7 |
| NCAAF | 2000/10/14 12:00 | Georgia Tech v Wake Forest | L | 52-20 |
| NCAAF | 2000/10/07 12:00 | Wake Forest v Vanderbilt | L | 10-17 |
| NCAAF | 2000/09/30 12:00 | Wake Forest v Virginia | L | 10-27 |