Head to Head
| Mexico Liga MX Femenil | 2019/04/02 03:00 | Leon (W) v Santos Laguna (W) | W | 1-0 |
| Mexico Liga MX Femenil | 2019/02/05 01:00 | Santos Laguna (W) v Leon (W) | W | 0-1 |
| Mexico Liga MX Femenil | 2018/10/26 00:00 | Leon (W) v Santos Laguna (W) | W | 3-0 |
| Mexico Liga MX Femenil | 2018/08/21 02:00 | Santos Laguna (W) v Leon (W) | W | 1-2 |
| Mexico Liga MX Femenil | 2018/03/20 03:00 | Santos Laguna (W) v Leon (W) | L | 4-2 |
| Mexico Liga MX Femenil | 2018/01/26 16:00 | Leon (W) v Santos Laguna (W) | L | 0-1 |
Home History
| Mexico Liga MX Femenil | 2019/04/28 21:00 | Club America (W) v Leon (W) | D | 1-1 |
| Mexico Liga MX Femenil | 2019/04/26 02:00 | Leon (W) v Club America (W) | L | 0-1 |
| Mexico Liga MX Femenil | 2019/04/22 21:00 | Mazatlan FC (W) v Leon (W) | W | 2-3 |
| Mexico Liga MX Femenil | 2019/04/16 02:00 | Leon (W) v Necaxa (W) | L | 0-1 |
| Mexico Liga MX Femenil | 2019/04/09 00:00 | Monterrey (W) v Leon (W) | L | 4-1 |
| Mexico Liga MX Femenil | 2019/04/02 03:00 | Leon (W) v Santos Laguna (W) | W | 1-0 |
| Mexico Liga MX Femenil | 2019/03/23 17:00 | Atlas (W) v Leon (W) | D | 2-2 |
| Mexico Liga MX Femenil | 2019/03/09 01:00 | Leon (W) v Queretaro (W) | W | 3-2 |
Away History
| Mexico Liga MX Femenil | 2019/04/19 23:00 | Monterrey (W) v Santos Laguna (W) | L | 3-2 |
| Mexico Liga MX Femenil | 2019/04/09 02:00 | Santos Laguna (W) v Atlas (W) | L | 0-2 |
| Mexico Liga MX Femenil | 2019/04/02 03:00 | Leon (W) v Santos Laguna (W) | L | 1-0 |
| Mexico Liga MX Femenil | 2019/03/26 03:00 | Santos Laguna (W) v Queretaro (W) | W | 2-1 |
| Mexico Liga MX Femenil | 2019/03/19 02:00 | Tigres UANL (W) v Santos Laguna (W) | L | 2-0 |
| Mexico Liga MX Femenil | 2019/03/12 03:00 | Santos Laguna (W) v Chivas Guadalajara (W) | W | 3-1 |
| Mexico Liga MX Femenil | 2019/03/03 18:00 | Mazatlan FC (W) v Santos Laguna (W) | D | 2-2 |
| Mexico Liga MX Femenil | 2019/02/26 02:00 | Santos Laguna (W) v Necaxa (W) | W | 3-0 |