Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2018/11/10 18:30 | Bluffton Beavers v Defiance Yellow Jackets | L | 34-7 |
| NCAAF | 2018/11/03 17:30 | Earlham Quakers v Defiance Yellow Jackets | W | 10-28 |
| NCAAF | 2018/10/27 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 6-35 |
| NCAAF | 2018/10/20 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 0-20 |
| NCAAF | 2018/10/13 17:30 | Hanover v Defiance Yellow Jackets | L | 48-7 |
| NCAAF | 2018/10/06 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 28-55 |
| NCAAF | 2018/09/22 17:30 | Defiance Yellow Jackets v Anderson Ravens | L | 14-18 |
| NCAAF | 2018/09/15 22:00 | Manchester Spartans v Defiance Yellow Jackets | L | 57-26 |
| NCAAF | 2018/11/10 18:30 | Anderson Ravens v Manchester Spartans | W | 6-35 |
| NCAAF | 2018/10/27 17:30 | Manchester Spartans v Franklin College Grizzlies | L | 24-45 |
| NCAAF | 2018/10/20 17:30 | Manchester Spartans v Hanover | L | 14-48 |
| NCAAF | 2018/10/13 17:30 | Bluffton Beavers v Manchester Spartans | W | 17-21 |
| NCAAF | 2018/10/06 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 49-27 |
| NCAAF | 2018/09/29 17:30 | Manchester Spartans v Earlham Quakers | W | 69-0 |
| NCAAF | 2018/09/22 23:00 | Rose Hulman Engineers v Manchester Spartans | L | 19-12 |
| NCAAF | 2018/09/15 22:00 | Manchester Spartans v Defiance Yellow Jackets | W | 57-26 |