[10] Serena Williams 6-3,6-4 Naomi Osaka [2] 2019-03-24 05:00
Stadium: Center Court Round: 27 Ground: Hardcourt outdoor
Head to Head
| US Open Women | 2018/09/08 20:00 | Serena Williams v Naomi Osaka | 2-6,4-6 |
| WTA Miami | 2018/03/21 20:35 | Serena Williams v Naomi Osaka | 3-6,2-6 |
Home History
| WTA Miami | 2019/03/22 20:35 | Rebecca Peterson v Serena Williams | 3-6,6-1,1-6 |
| WTA Indian Wells | 2019/03/09 02:00 | Victoria Azarenka v Serena Williams | 5-7,3-6 |
| Australian Open Women | 2019/01/23 02:00 | Serena Williams v Karolina Pliskova | 4-6,6-4,5-7 |
| Australian Open Women | 2019/01/21 08:00 | Simona Halep v Serena Williams | 1-6,6-4,4-6 |
| Australian Open Women | 2019/01/19 03:25 | Dayana Yastremska v Serena Williams | 2-6,1-6 |
| Australian Open Women | 2019/01/17 09:20 | Eugenie Bouchard v Serena Williams | 2-6,2-6 |
| Australian Open Women | 2019/01/15 01:35 | Tatjana Maria v Serena Williams | 0-6,2-6 |
| Hopman Cup Women | 2019/01/03 03:30 | Katie Boulter v Serena Williams | 1-6,6-7 |
Away History
| WTA Miami | 2019/03/23 18:55 | Naomi Osaka v Su-Wei Hsieh | 6-4,6-7,3-6 |
| WTA Miami | 2019/03/22 16:00 | Naomi Osaka v Yanina Wickmayer | 6-0,6-7,6-1 |
| WTA Indian Wells | 2019/03/13 00:55 | Naomi Osaka v Belinda Bencic | 3-6,1-6 |
| WTA Indian Wells | 2019/03/12 01:00 | Naomi Osaka v Danielle Rose Collins | 6-4,6-2 |
| WTA Indian Wells | 2019/03/10 04:00 | Naomi Osaka v Kristina Mladenovic | 6-3,6-4 |
| WTA Dubai | 2019/02/19 15:25 | Naomi Osaka v Kristina Mladenovic | 3-6,3-6 |
| Australian Open Women | 2019/01/26 08:30 | Naomi Osaka v Petra Kvitova | 7-6,5-7,6-4 |
| Australian Open Women | 2019/01/24 04:55 | Karolina Pliskova v Naomi Osaka | 2-6,6-4,4-6 |