[10] Serena Williams 6-4,6-3 Laura Siegemund [73] 2019-09-29 22:15
Stadium: Stadium Court Round: 27 Ground: Hardcourt outdoor
Home History
| US Open Women | 2019/09/07 20:00 | Bianca Andreescu v Serena Williams | 6-3,7-5 |
| US Open Women | 2019/09/05 23:00 | Elina Svitolina v Serena Williams | 3-6,1-6 |
| US Open Women | 2019/09/03 23:00 | Serena Williams v Qiang Wang | 6-1,6-0 |
| US Open Women | 2019/09/01 17:45 | Serena Williams v Petra Martic | 6-3,6-4 |
| US Open Women | 2019/08/30 17:40 | Serena Williams v Karolina Muchova | 6-3,6-2 |
| US Open Women | 2019/08/29 01:45 | Serena Williams v Caty McNally | 5-7,6-3,6-1 |
| US Open Women | 2019/08/26 23:00 | Serena Williams v Maria Sharapova | 6-1,6-1 |
| WTA Toronto | 2019/08/10 22:00 | Marie Bouzkova v Serena Williams | 6-1,3-6,3-6 |
Away History
| WTA Guangzhou | 2019/09/17 10:00 | Sofia Kenin v Laura Siegemund | 6-4,6-2 |
| WTA Hiroshima | 2019/09/13 07:55 | Laura Siegemund v Veronika Kudermetova | 3-6,6-4,2-6 |
| WTA Hiroshima | 2019/09/11 02:30 | Laura Siegemund v Patricia Maria Tig | 6-2,5-7,7-5 |
| WTA Hiroshima | 2019/09/10 04:10 | Laura Siegemund v Valeria Savinykh | 6-4,6-1 |
| US Open Women | 2019/08/29 15:00 | Sofia Kenin v Laura Siegemund | 7-6,6-0 |
| US Open Women | 2019/08/26 21:55 | Magdalena Frech v Laura Siegemund | 7-5,3-6,4-6 |
| WTA New York | 2019/08/19 19:10 | Laura Siegemund v Mihaela Buzarnescu | 6-3,0-6,4-6 |
| WTA New York | 2019/08/18 14:00 | Jil Teichmann v Laura Siegemund | 0-6,7-6,7-6 |