[10] NY Islanders 2-4 BUF Sabres [31] 2021-03-26 05:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Barry Trotz
Head to Head
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | W | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | W | 3-1 |
| NHL | 2019/12/14 18:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2019/11/02 23:00 | NY Islanders v BUF Sabres | W | 1-0 |
Home History
| NHL | 2021/03/25 23:00 | NY Islanders v BOS Bruins | W | 4-3 |
| NHL | 2021/03/22 23:00 | NY Islanders v PHI Flyers | W | 2-1 |
| NHL | 2021/03/20 23:00 | PHI Flyers v NY Islanders | W | 1-6 |
| NHL | 2021/03/18 23:00 | PHI Flyers v NY Islanders | L | 4-3 |
| NHL | 2021/03/16 23:00 | NY Islanders v WAS Capitals | L | 1-3 |
| NHL | 2021/03/14 21:00 | NY Islanders v NJ Devils | W | 3-2 |
| NHL | 2021/03/14 00:00 | NY Islanders v NJ Devils | W | 3-2 |
| NHL | 2021/03/12 00:00 | NJ Devils v NY Islanders | W | 3-5 |
Away History
| NHL | 2021/03/25 23:00 | BUF Sabres v PIT Penguins | L | 0-4 |
| NHL | 2021/03/25 00:00 | BUF Sabres v PIT Penguins | L | 2-5 |
| NHL | 2021/03/22 23:00 | BUF Sabres v NY Rangers | L | 3-5 |
| NHL | 2021/03/18 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/03/16 23:00 | BUF Sabres v NJ Devils | L | 2-3 |
| NHL | 2021/03/15 23:00 | WAS Capitals v BUF Sabres | L | 6-0 |
| NHL | 2021/03/14 00:00 | PIT Penguins v BUF Sabres | L | 3-0 |
| NHL | 2021/03/12 00:00 | PIT Penguins v BUF Sabres | L | 5-2 |