[10] LA Chargers 29-41 HOU Texans [30] 2021-10-02 18:00
Stadium: NRG Stadium Round: 1
Home Manager: David Culley Away Manager: Brandon Staley
Head to Head
| NFL | 2019/09/22 20:25 | HOU Texans v LA Chargers | L | 27-20 |
| NFL | 2016/11/27 18:00 | LA Chargers v HOU Texans | W | 21-13 |
Home History
| NFL | 2021/09/26 17:00 | LA Chargers v KC Chiefs | W | 30-24 |
| NFL | 2021/09/19 20:25 | DAL Cowboys v LA Chargers | L | 20-17 |
| NFL | 2021/09/12 17:00 | LA Chargers v WAS Commanders | W | 20-16 |
| NFL Preseason | 2021/08/29 02:00 | LA Chargers v SEA Seahawks | L | 0-27 |
| NFL Preseason | 2021/08/22 23:30 | SF 49ers v LA Chargers | L | 15-10 |
| NFL Preseason | 2021/08/15 02:00 | LA Chargers v LA Rams | W | 13-6 |
| NFL | 2021/01/03 21:25 | LA Chargers v KC Chiefs | W | 38-21 |
| NFL | 2020/12/27 21:05 | DEN Broncos v LA Chargers | W | 16-19 |
Away History
| NFL | 2021/09/24 00:20 | CAR Panthers v HOU Texans | L | 24-9 |
| NFL | 2021/09/19 17:00 | HOU Texans v CLE Browns | L | 21-31 |
| NFL | 2021/09/12 17:00 | JAX Jaguars v HOU Texans | W | 21-37 |
| NFL Preseason | 2021/08/29 00:00 | TB Buccaneers v HOU Texans | L | 23-16 |
| NFL Preseason | 2021/08/22 00:00 | HOU Texans v DAL Cowboys | W | 20-14 |
| NFL Preseason | 2021/08/15 00:00 | HOU Texans v GB Packers | W | 26-7 |
| NFL | 2021/01/03 21:25 | TEN Titans v HOU Texans | L | 41-38 |
| NFL | 2020/12/27 18:00 | CIN Bengals v HOU Texans | L | 37-31 |