[29] HOU Texans 7-23 SF 49ers [15] 2021-10-29 01:05
Stadium: Levi's Stadium Round: 1
Home Manager: Kyle Shanahan Away Manager: David Culley
Head to Head
| NFL Preseason | 2018/08/19 00:00 | SF 49ers v HOU Texans | W | 13-16 |
| NFL | 2017/12/10 18:00 | SF 49ers v HOU Texans | L | 26-16 |
| NFL Preseason | 2016/08/14 23:00 | SF 49ers v HOU Texans | W | 13-24 |
Home History
| NFL | 2021/10/24 20:25 | HOU Texans v ARZ Cardinals | L | 5-31 |
| NFL | 2021/10/17 17:00 | HOU Texans v IND Colts | L | 3-31 |
| NFL | 2021/10/10 17:00 | NE Patriots v HOU Texans | L | 25-22 |
| NFL | 2021/10/03 17:00 | HOU Texans v BUF Bills | L | 0-40 |
| NFL | 2021/09/24 00:20 | CAR Panthers v HOU Texans | L | 24-9 |
| NFL | 2021/09/19 17:00 | HOU Texans v CLE Browns | L | 21-31 |
| NFL | 2021/09/12 17:00 | JAX Jaguars v HOU Texans | W | 21-37 |
| NFL Preseason | 2021/08/29 00:00 | TB Buccaneers v HOU Texans | L | 23-16 |
Away History
| NFL | 2021/10/25 00:20 | IND Colts v SF 49ers | L | 30-18 |
| NFL | 2021/10/10 20:25 | SF 49ers v ARZ Cardinals | L | 10-17 |
| NFL | 2021/10/03 20:05 | SEA Seahawks v SF 49ers | L | 28-21 |
| NFL | 2021/09/27 00:20 | GB Packers v SF 49ers | L | 30-28 |
| NFL | 2021/09/19 17:00 | SF 49ers v PHI Eagles | W | 17-11 |
| NFL | 2021/09/12 17:00 | SF 49ers v DET Lions | W | 41-33 |
| NFL Preseason | 2021/08/29 20:00 | LV Raiders v SF 49ers | W | 10-34 |
| NFL Preseason | 2021/08/22 23:30 | SF 49ers v LA Chargers | W | 15-10 |