[1] Cruz Azul 1-1 Santos Laguna [5] 2021-02-23 09:15
Stadium: Estadio Azteca Round: 1
Referee: Fernando Hernandez Gomez Home Manager: Luis Armando Gonzalez Bejarano Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | L | 1-0 |
| Mexico Liga MX | 2020/07/26 02:00 | Cruz Azul v Santos Laguna | W | 2-0 |
| Mexico Liga MX | 2020/01/25 23:00 | Cruz Azul v Santos Laguna | W | 3-0 |
| Mexico Liga MX | 2019/11/11 00:45 | Santos Laguna v Cruz Azul | L | 3-1 |
| Mexico Liga MX | 2019/02/16 23:00 | Cruz Azul v Santos Laguna | L | 1-2 |
| Mexico Liga MX | 2018/08/26 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Mexico Liga MX | 2018/02/26 00:00 | Santos Laguna v Cruz Azul | L | 2-0 |
| Mexico Liga MX | 2017/09/16 22:00 | Cruz Azul v Santos Laguna | W | 2-1 |
Home History
| Mexico Liga MX | 2021/02/21 01:00 | Cruz Azul v Toluca | W | 3-2 |
| Mexico Liga MX | 2021/02/18 03:00 | Tigres UANL v Cruz Azul | W | 0-2 |
| Mexico Liga MX | 2021/02/06 03:30 | Necaxa v Cruz Azul | W | 0-2 |
| Mexico Liga MX | 2021/01/31 03:00 | Cruz Azul v Queretaro | W | 4-1 |
| Mexico Liga MX | 2021/01/26 03:00 | Pachuca v Cruz Azul | W | 0-1 |
| Mexico Liga MX | 2021/01/17 01:00 | Cruz Azul v Puebla | L | 0-1 |
| Mexico Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | L | 1-0 |
| CONCACAF Champions Cup | 2020/12/17 03:30 | Los Angeles FC v Cruz Azul | L | 2-1 |
Away History
| Mexico Liga MX | 2021/02/19 03:00 | Atletico San Luis v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | W | 1-0 |
| Mexico Liga MX | 2021/02/06 23:00 | Atlas v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/02/01 01:06 | Santos Laguna v Club America | D | 1-1 |
| Mexico Liga MX | 2021/01/23 03:30 | Mazatlan FC v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2021/01/18 01:06 | Santos Laguna v Tigres UANL | W | 2-0 |
| Mexico Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | W | 1-0 |
| Mexico Liga MX | 2020/11/22 01:00 | Santos Laguna v Pachuca | L | 0-3 |