[10] Santos Laguna 1-2 Monterrey [4] 2021-08-15 12:06
Stadium: Estadio TSM Corona Round: 10
Referee: Marco Antonio Ortiz Nava Home Manager: Guillermo Almada Away Manager: Javier Aguirre
Head to Head
| Mexico Liga MX | 2021/05/16 23:00 | Monterrey v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | W | 2-1 |
| Mexico Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | W | 1-0 |
| Mexico Liga MX | 2020/08/09 00:06 | Monterrey v Santos Laguna | D | 2-2 |
| Mexico Cup | 2020/02/20 01:00 | Monterrey v Santos Laguna | L | 1-0 |
| Mexico Cup | 2020/02/12 01:00 | Santos Laguna v Monterrey | D | 0-0 |
| Mexico Liga MX | 2019/12/02 01:00 | Santos Laguna v Monterrey | D | 1-1 |
| Mexico Liga MX | 2019/11/29 01:06 | Monterrey v Santos Laguna | L | 5-2 |
Home History
| Leagues Cup | 2021/08/12 23:00 | Orlando City SC v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2021/08/08 02:00 | Tigres UANL v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/08/01 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Mexico Liga MX | 2021/07/24 00:00 | Necaxa v Santos Laguna | W | 0-3 |
| Club Friendly List | 2021/07/05 00:30 | Club America v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/05/28 02:00 | Santos Laguna v Cruz Azul | L | 0-1 |
| Mexico Liga MX | 2021/05/24 00:00 | Puebla v Santos Laguna | L | 1-0 |
Away History
| Mexico Liga MX | 2021/08/15 02:06 | Monterrey v Pachuca | W | 3-1 |
| CONCACAF Champions Cup | 2021/08/12 02:00 | Monterrey v Cruz Azul | W | 1-0 |
| Mexico Liga MX | 2021/08/07 00:00 | Mazatlan FC v Monterrey | D | 1-1 |
| Mexico Liga MX | 2021/08/01 02:00 | Monterrey v Unam Pumas | W | 2-0 |
| Mexico Liga MX | 2021/07/26 00:06 | Monterrey v Puebla | D | 1-1 |
| Club Friendly List | 2021/07/11 21:00 | Chivas Guadalajara v Monterrey | W | 0-1 |
| Club Friendly List | 2021/07/05 00:00 | Rio Grande Valley FC Toros v Monterrey | W | 1-5 |
| World Club Friendlies | 2021/06/27 01:00 | Cancun FC v Monterrey | D | 1-1 |