[3] Mainz II 2-0 FC Giessen [17] 2021-10-03 15:00
Stadium: Stadion am Bruchweg Round: 21
Referee: Sascha Kief Home Manager: Bartosch Gaul Away Manager: Daniyel Cimen
Head to Head
| Germany Regionalliga South West | 2021/08/21 12:00 | FC Giessen v Mainz II | W | 0-1 |
| Germany Regionalliga South West | 2021/03/20 13:00 | FC Giessen v Mainz II | D | 1-1 |
| Germany Regionalliga South West | 2021/01/12 18:00 | Mainz II v FC Giessen | W | 2-1 |
| Germany Regionalliga South West | 2019/09/15 12:00 | Mainz II v FC Giessen | L | 1-3 |
Home History
| Germany Regionalliga South West | 2021/10/02 12:00 | Mainz II v Rot-Weiss Koblenz | W | 2-1 |
| Germany Regionalliga South West | 2021/09/28 17:00 | SSV Ulm 1846 v Mainz II | W | 0-2 |
| Germany Regionalliga South West | 2021/09/25 12:00 | Mainz II v Kickers Offenbach | W | 2-0 |
| Germany Regionalliga South West | 2021/09/18 12:00 | Elversberg v Mainz II | L | 5-0 |
| Germany Regionalliga South West | 2021/09/14 16:00 | Mainz II v FC 08 Homburg | L | 1-2 |
| Germany Regionalliga South West | 2021/09/10 17:00 | FSV Frankfurt v Mainz II | W | 1-2 |
| Germany Regionalliga South West | 2021/09/03 12:00 | Mainz II v VfB Stuttgart II | L | 2-4 |
| Germany Regionalliga South West | 2021/08/29 12:00 | SG Sonnenhof Grossaspach v Mainz II | W | 1-3 |
Away History
| Germany Regionalliga South West | 2021/10/02 12:00 | FC Giessen v VfB Stuttgart II | W | 2-1 |
| Germany Regionalliga South West | 2021/09/28 17:00 | SG Sonnenhof Grossaspach v FC Giessen | D | 1-1 |
| Germany Regionalliga South West | 2021/09/25 12:00 | FC Giessen v TSV Steinbach | L | 1-3 |
| Germany Regionalliga South West | 2021/09/14 17:00 | VfR Aalen v FC Giessen | L | 1-0 |
| Germany Regionalliga South West | 2021/09/11 12:00 | FC Giessen v TSG Balingen | W | 3-1 |
| Germany Regionalliga South West | 2021/09/04 12:00 | Bahlinger SC v FC Giessen | L | 2-0 |
| Germany Regionalliga South West | 2021/08/28 12:00 | FC Giessen v Pirmasens | L | 0-1 |
| Germany Regionalliga South West | 2021/08/24 17:00 | TSV Schott Mainz v FC Giessen | L | 1-0 |