[7] Arsenal 3-0 Southampton [16] 2021-11-17 01:00
Stadium: Emirates Stadium Round: 16
Referee: Jarred Gillett Home Manager: Mikel Arteta Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2021/01/26 20:15 | Southampton v Arsenal | W | 1-3 |
| England FA Cup | 2021/01/23 12:15 | Southampton v Arsenal | L | 1-0 |
| England Premier League | 2020/12/16 18:00 | Arsenal v Southampton | D | 1-1 |
| England Premier League | 2020/06/25 17:00 | Southampton v Arsenal | W | 0-2 |
| England Premier League | 2019/11/23 15:00 | Arsenal v Southampton | D | 2-2 |
| England Premier League | 2019/02/24 14:05 | Arsenal v Southampton | W | 2-0 |
| England Premier League | 2018/12/16 13:30 | Southampton v Arsenal | L | 3-2 |
| England Premier League | 2018/04/08 13:15 | Arsenal v Southampton | W | 3-2 |
Home History
| England Premier League | 2021/11/07 14:00 | Arsenal v Watford | W | 1-0 |
| England Premier League | 2021/10/30 11:30 | Leicester v Arsenal | W | 0-2 |
| England EFL Cup | 2021/10/26 18:45 | Arsenal v Leeds | W | 2-0 |
| England Premier League | 2021/10/22 19:00 | Arsenal v Aston Villa | W | 3-1 |
| England Premier League | 2021/10/18 19:00 | Arsenal v Crystal Palace | D | 2-2 |
| England Premier League | 2021/10/02 16:30 | Brighton v Arsenal | D | 0-0 |
| England Premier League | 2021/09/26 15:30 | Arsenal v Tottenham | W | 3-1 |
| England EFL Cup | 2021/09/22 18:45 | Arsenal v AFC Wimbledon | W | 3-0 |
Away History
| England Premier League | 2021/11/05 20:00 | Southampton v Aston Villa | W | 1-0 |
| England Premier League | 2021/10/30 14:00 | Watford v Southampton | W | 0-1 |
| England EFL Cup | 2021/10/26 18:45 | Chelsea v Southampton | L | 5-4 |
| England Premier League | 2021/10/23 14:00 | Southampton v Burnley | D | 2-2 |
| England Premier League | 2021/10/16 14:00 | Southampton v Leeds | W | 1-0 |
| England Premier League | 2021/10/02 14:00 | Chelsea v Southampton | L | 3-1 |
| England Premier League | 2021/09/26 13:00 | Southampton v Wolverhampton | L | 0-1 |
| England EFL Cup | 2021/09/21 18:45 | Sheff Utd v Southampton | W | 4-6 |