[7] Cologne II 2-1 Schalke II [14] 2021-10-27 01:00
Stadium: Franz-Kremer-Stadion Round: 20
Referee: Francisco-Javier Lahora Chulian Home Manager: Mark Zimmermann Away Manager: Torsten Frohling
Head to Head
| Germany Regionalliga West | 2021/08/15 13:00 | Schalke II v Cologne II | W | 1-2 |
| Germany Regionalliga West | 2021/03/20 14:30 | Cologne II v Schalke II | W | 5-2 |
| Germany Regionalliga West | 2020/10/21 17:30 | Schalke II v Cologne II | L | 3-0 |
| Germany Regionalliga West | 2019/11/09 13:00 | Cologne II v Schalke II | W | 3-0 |
| Germany Regionalliga West | 2016/12/03 13:00 | Cologne II v Schalke II | W | 2-1 |
| Germany Regionalliga West | 2016/08/05 12:00 | Schalke II v Cologne II | W | 0-1 |
| Germany Regionalliga West | 2016/03/11 18:30 | Cologne II v Schalke II | L | 0-1 |
| Germany Regionalliga West | 2015/09/19 12:00 | Schalke II v Cologne II | D | 1-1 |
Home History
| Germany Regionalliga West | 2021/10/23 12:00 | Cologne II v Rot-Weiss Essen | D | 1-1 |
| Germany Regionalliga West | 2021/10/15 17:00 | Rot Weiss Ahlen v Cologne II | W | 2-6 |
| Germany Regionalliga West | 2021/10/01 17:00 | FC Wegberg-Beeck v Cologne II | W | 0-1 |
| Germany Regionalliga West | 2021/09/28 17:30 | SC Wiedenbruck v Cologne II | L | 2-0 |
| Germany Regionalliga West | 2021/09/25 12:00 | Cologne II v Sportfreunde Lotte | W | 4-0 |
| Germany Regionalliga West | 2021/09/18 12:00 | Borussia M'gladbach II v Cologne II | L | 3-1 |
| Germany Regionalliga West | 2021/09/15 17:30 | Cologne II v Alemannia Aachen | L | 1-3 |
| Germany Regionalliga West | 2021/09/10 17:30 | Cologne II v Bonner SC | W | 3-2 |
Away History
| Germany Regionalliga West | 2021/10/23 12:00 | Schalke II v VfB Homberg | D | 0-0 |
| Germany Regionalliga West | 2021/10/15 16:30 | Fortuna Dusseldorf II v Schalke II | L | 5-1 |
| Germany Regionalliga West | 2021/10/12 12:00 | Schalke II v SC Fortuna Köln | D | 1-1 |
| Germany Regionalliga West | 2021/10/02 12:00 | Wuppertaler v Schalke II | L | 3-0 |
| Germany Regionalliga West | 2021/09/25 12:00 | Schalke II v SV Straelen | D | 1-1 |
| Germany Regionalliga West | 2021/09/17 17:30 | Rot-Weiss Essen v Schalke II | L | 1-0 |
| Germany Regionalliga West | 2021/09/14 17:30 | Schalke II v Rot Weiss Ahlen | W | 5-3 |
| Germany Regionalliga West | 2021/09/10 16:30 | SV Rodinghausen v Schalke II | L | 1-0 |