Head to Head
| Mexico Liga MX Femenil | 2021/02/04 23:00 | Leon (W) v Santos Laguna (W) | W | 2-1 |
| Mexico Liga MX Femenil | 2020/09/22 00:00 | Santos Laguna (W) v Leon (W) | D | 1-1 |
| Mexico Liga MX Femenil | 2020/02/25 03:00 | Santos Laguna (W) v Leon (W) | W | 1-2 |
| Mexico Liga MX Femenil | 2019/09/24 00:00 | Leon (W) v Santos Laguna (W) | W | 2-0 |
| Mexico Liga MX Femenil | 2019/04/02 03:00 | Leon (W) v Santos Laguna (W) | W | 1-0 |
| Mexico Liga MX Femenil | 2019/02/05 01:00 | Santos Laguna (W) v Leon (W) | W | 0-1 |
| Mexico Liga MX Femenil | 2018/10/26 00:00 | Leon (W) v Santos Laguna (W) | W | 3-0 |
| Mexico Liga MX Femenil | 2018/08/21 02:00 | Santos Laguna (W) v Leon (W) | W | 1-2 |
Home History
| Mexico Liga MX Femenil | 2021/05/02 15:00 | Juarez FC (W) v Leon (W) | L | 2-1 |
| Mexico Liga MX Femenil | 2021/04/27 00:00 | Leon (W) v Puebla (W) | W | 2-1 |
| Mexico Liga MX Femenil | 2021/04/19 21:00 | Leon (W) v Atletico San Luis (W) | W | 3-2 |
| Mexico Liga MX Femenil | 2021/04/02 23:00 | Queretaro (W) v Leon (W) | L | 1-0 |
| Mexico Liga MX Femenil | 2021/03/30 01:00 | Leon (W) v Tijuana (W) | W | 2-1 |
| Mexico Liga MX Femenil | 2021/03/20 18:00 | Unam Pumas (W) v Leon (W) | L | 2-0 |
| Mexico Liga MX Femenil | 2021/03/15 23:00 | Pachuca (W) v Leon (W) | L | 2-0 |
| Mexico Liga MX Femenil | 2021/03/12 01:00 | Leon (W) v Monterrey (W) | L | 0-3 |
Away History
| Mexico Liga MX Femenil | 2021/05/01 15:00 | Mazatlan FC (W) v Santos Laguna (W) | W | 2-3 |
| Mexico Liga MX Femenil | 2021/04/27 00:00 | Santos Laguna (W) v Juarez FC (W) | W | 3-0 |
| Mexico Liga MX Femenil | 2021/04/19 21:00 | Toluca (W) v Santos Laguna (W) | L | 1-0 |
| Mexico Liga MX Femenil | 2021/04/06 00:00 | Santos Laguna (W) v Club America (W) | L | 1-2 |
| Mexico Liga MX Femenil | 2021/03/29 22:30 | Santos Laguna (W) v Cruz Azul (W) | W | 2-1 |
| Mexico Liga MX Femenil | 2021/03/21 23:00 | Atletico San Luis (W) v Santos Laguna (W) | D | 2-2 |
| Mexico Liga MX Femenil | 2021/03/16 01:00 | Tijuana (W) v Santos Laguna (W) | W | 0-1 |
| Mexico Liga MX Femenil | 2021/03/11 22:00 | Santos Laguna (W) v Unam Pumas (W) | D | 2-2 |