Head to Head
| England Premier League 2 | 2021/10/01 15:00 | Southampton U23 v Stoke U23 | D | 1-1 |
| England U23 Premier League Cup | 2020/02/25 14:00 | Stoke U23 v Southampton U23 | W | 4-1 |
| England U23 Premier League Cup | 2019/10/05 14:00 | Southampton U23 v Stoke U23 | D | 1-1 |
| England Premier League 2 | 2019/01/04 19:00 | Southampton U23 v Stoke U23 | L | 2-0 |
| England Premier League 2 | 2018/08/20 18:00 | Stoke U23 v Southampton U23 | L | 1-4 |
| England Premier League 2 | 2018/01/29 19:00 | Stoke U23 v Southampton U23 | L | 0-2 |
| England Premier League 2 | 2017/09/18 18:00 | Southampton U23 v Stoke U23 | L | 3-0 |
Home History
| England Premier League 2 | 2021/11/07 15:00 | Stoke U23 v Sunderland U23 | D | 2-2 |
| England Premier League 2 | 2021/11/01 19:00 | Stoke U23 v Wolverhampton U23 | W | 2-0 |
| England Premier League 2 | 2021/10/25 12:00 | West Brom U23 v Stoke U23 | D | 1-1 |
| England Premier League 2 | 2021/10/18 18:00 | Stoke U23 v Nottm Forest U23 | W | 1-0 |
| England U23 Premier League Cup | 2021/10/08 18:00 | Fulham U23 v Stoke U23 | L | 2-1 |
| England Premier League 2 | 2021/10/01 15:00 | Southampton U23 v Stoke U23 | D | 1-1 |
| England Premier League 2 | 2021/09/27 18:00 | Stoke U23 v Aston Villa U23 | L | 0-8 |
| England Premier League 2 | 2021/09/20 18:00 | Newcastle U23 v Stoke U23 | W | 2-3 |
Away History
| England Premier League 2 | 2021/11/05 12:00 | Southampton U23 v Newcastle U23 | W | 5-0 |
| England Premier League 2 | 2021/10/31 14:00 | Southampton U23 v Aston Villa U23 | W | 4-0 |
| England Premier League 2 | 2021/10/25 18:00 | Reading U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2021/10/18 11:00 | Wolverhampton U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2021/10/01 15:00 | Southampton U23 v Stoke U23 | D | 1-1 |
| England Premier League 2 | 2021/09/27 12:30 | Birmingham U23 v Southampton U23 | L | 3-2 |
| England U23 Premier League Cup | 2021/09/23 18:00 | Southampton U23 v West Brom U23 | L | 0-6 |
| England Premier League 2 | 2021/09/19 13:00 | Southampton U23 v Burnley U23 | L | 0-2 |