Stadium: Toumba Stadium Round: 20
Referee: Luis Miguel Branco Godinho Home Manager: Razvan Lucescu Away Manager: Pedro Martins
| Greece Super League 1 | 2021/10/24 17:30 | Olympiacos v PAOK Salonika | L | 2-1 |
| Greece Cup | 2021/05/22 18:00 | Olympiacos v PAOK Salonika | W | 1-2 |
| Greece Super League 1 | 2021/05/12 16:30 | Olympiacos v PAOK Salonika | L | 1-0 |
| Greece Super League 1 | 2021/04/18 16:30 | PAOK Salonika v Olympiacos | W | 2-0 |
| Greece Super League 1 | 2021/01/27 17:30 | Olympiacos v PAOK Salonika | L | 3-0 |
| Greece Super League 1 | 2021/01/13 17:30 | PAOK Salonika v Olympiacos | D | 1-1 |
| Greece Super League 1 | 2020/07/12 18:45 | Olympiacos v PAOK Salonika | W | 0-1 |
| Greece Cup | 2020/06/24 18:30 | Olympiacos v PAOK Salonika | L | 2-0 |
| Greece Cup | 2021/12/22 15:00 | PAOK Salonika v Larissa | W | 3-1 |
| Greece Super League 1 | 2021/12/19 17:30 | PAOK Salonika v Asteras Tripolis | W | 3-2 |
| Greece Super League 1 | 2021/12/15 15:15 | Giannina v PAOK Salonika | W | 0-4 |
| Greece Super League 1 | 2021/12/12 15:15 | PAOK Salonika v Lamia | W | 2-1 |
| UEFA Conference League | 2021/12/09 20:00 | PAOK Salonika v Lincoln Red Imps FC | W | 2-0 |
| Greece Super League 1 | 2021/12/05 15:15 | Ionikos Nikea v PAOK Salonika | L | 3-2 |
| Greece Cup | 2021/12/01 19:30 | Larissa v PAOK Salonika | D | 1-1 |
| Greece Super League 1 | 2021/11/28 17:30 | PAOK Salonika v Aris Salonika | L | 0-1 |
| Greece Cup | 2021/12/22 17:00 | Olympiacos v Levadiakos | W | 2-0 |
| Greece Super League 1 | 2021/12/19 13:00 | Olympiacos v Lamia | W | 1-0 |
| Greece Super League 1 | 2021/12/15 17:30 | Atromitos Athinon v Olympiacos | W | 0-3 |
| Greece Super League 1 | 2021/12/12 17:30 | Olympiacos v Aris Salonika | W | 1-0 |
| UEFA Europa League | 2021/12/09 17:45 | Antwerp v Olympiacos | L | 1-0 |
| Greece Super League 1 | 2021/12/04 17:30 | OFI Crete v Olympiacos | W | 1-3 |
| Greece Cup | 2021/12/01 15:00 | Levadiakos v Olympiacos | L | 3-2 |
| Greece Super League 1 | 2021/11/28 13:00 | Olympiacos v Volos NFC | W | 2-1 |