[6] Guimaraes 1-1 Santa Clara [9] 2022-01-24 12:30
Stadium: Dom Afonso Henriques Round: 32
Referee: Hugo Serafim Coelho Magalhaes Silva Home Manager: Pepa Away Manager: Mario Silva
Head to Head
| Portugal Primeira Liga | 2021/12/17 19:00 | Santa Clara v Guimaraes | L | 1-0 |
| Portugal Primeira Liga | 2021/04/17 14:30 | Guimaraes v Santa Clara | W | 1-0 |
| Portugal Primeira Liga | 2020/12/21 20:15 | Santa Clara v Guimaraes | W | 0-4 |
| Portugal Cup | 2020/12/13 14:00 | Guimaraes v Santa Clara | L | 0-1 |
| Portugal Primeira Liga | 2020/07/24 18:00 | Santa Clara v Guimaraes | D | 2-2 |
| Portugal Primeira Liga | 2020/01/18 15:30 | Guimaraes v Santa Clara | W | 1-0 |
| Portugal Primeira Liga | 2019/03/30 20:30 | Santa Clara v Guimaraes | L | 1-0 |
| Portugal Primeira Liga | 2018/11/11 15:00 | Guimaraes v Santa Clara | W | 2-0 |
Home History
| Portugal Primeira Liga | 2022/01/23 15:30 | Guimaraes v Estoril | W | 3-1 |
| Portugal Primeira Liga | 2022/01/17 20:15 | Portimonense v Guimaraes | D | 1-1 |
| Portugal Primeira Liga | 2022/01/10 20:15 | Gil Vicente v Guimaraes | L | 3-2 |
| Portugal Primeira Liga | 2021/12/29 19:00 | Guimaraes v Boavista | D | 1-1 |
| Portugal Primeira Liga | 2021/12/17 19:00 | Santa Clara v Guimaraes | L | 1-0 |
| Portugal Primeira Liga | 2021/12/11 18:00 | Guimaraes v Tondela | W | 5-2 |
| Portugal Primeira Liga | 2021/12/04 20:30 | Pacos Ferreira v Guimaraes | W | 1-2 |
| Portugal Primeira Liga | 2021/11/28 20:30 | FC Porto v Guimaraes | L | 2-1 |
Away History
| Portugal Primeira Liga | 2022/01/22 15:30 | Moreirense v Santa Clara | W | 0-2 |
| Portugal Primeira Liga | 2022/01/16 15:30 | Santa Clara v Tondela | D | 2-2 |
| Portugal Primeira Liga | 2022/01/07 18:30 | Santa Clara v Sporting | W | 3-2 |
| Portugal Primeira Liga | 2021/12/30 17:00 | Pacos Ferreira v Santa Clara | L | 2-1 |
| Portugal Primeira Liga | 2021/12/17 19:00 | Santa Clara v Guimaraes | W | 1-0 |
| Portugal Primeira Liga | 2021/12/11 15:30 | Maritimo v Santa Clara | L | 4-1 |
| Portugal Primeira Liga | 2021/12/05 15:30 | Santa Clara v Arouca | W | 2-1 |
| Portugal Primeira Liga | 2021/11/29 20:15 | Estoril v Santa Clara | D | 2-2 |