Illinois State 17-35 Southern Illinois 2021-05-14 05:00
Stadium: Saluki Stadium Round: 1
Home Manager: Brock Spack Away Manager: Nick Hill
Head to Head
| NCAAF | 2019/10/12 23:00 | Illinois State v SO Illinois | W | 21-7 |
| NCAAF | 2018/10/13 19:00 | SO Illinois v Illinois State | W | 3-51 |
| NCAAF | 2017/10/14 19:00 | SO Illinois v Illinois State | L | 42-7 |
Home History
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | W | 18-26 |
| NCAAF | 2021/03/13 20:30 | Illinois State v North Dakota State | L | 13-21 |
| NCAAF | 2021/03/06 22:00 | Illinois State v Northern Iowa | L | 10-20 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | L | 27-20 |
| NCAAF | 2019/12/14 17:00 | Illinois State v North Dakota State | L | 3-9 |
| NCAAF | 2019/12/07 20:00 | Illinois State v Central Arkansas | W | 24-14 |
| NCAAF | 2019/11/30 19:00 | Illinois State v SE Missouri St | W | 24-6 |
| NCAAF | 2019/11/23 17:00 | Illinois State v Youngstown State | L | 3-21 |
Away History
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/04/24 20:00 | SO Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | W | 48-55 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | W | 16-17 |
| NCAAF | 2021/03/06 17:00 | SO Illinois v Youngstown State | W | 30-22 |
| NCAAF | 2021/02/27 18:00 | North Dakota State v SO Illinois | W | 14-38 |