South Dakota 34-21 Northern Iowa 2021-10-01 21:00
Stadium: UNI-Dome Round: 1
Home Manager: Bob Nielson Away Manager: Mark Farley
Head to Head
| NCAAF | 2019/10/19 21:00 | South Dakota v Northern Iowa | L | 27-42 |
| NCAAF | 2018/10/13 23:00 | Northern Iowa v South Dakota | L | 42-28 |
| NCAAF | 2017/11/04 18:00 | Northern Iowa v South Dakota | L | 34-29 |
Home History
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | L | 23-31 |
| NCAAF | 2021/09/19 00:00 | South Dakota v Cal Poly | W | 48-14 |
| NCAAF | 2021/09/11 18:00 | Northern Arizona v South Dakota | W | 7-34 |
| NCAAF | 2021/09/04 00:00 | South Dakota v Kansas | L | 14-17 |
| NCAAF | 2021/03/20 16:00 | South Dakota v Youngstown State | L | 10-28 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | L | 27-24 |
| NCAAF | 2021/03/04 23:00 | South Dakota v North Dakota | L | 10-21 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | W | 27-20 |
Away History
| NCAAF | 2021/09/12 01:00 | Northern Iowa v CS Sacramento | W | 34-16 |
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | L | 10-16 |
| NCAAF | 2021/04/10 21:00 | North Dakota State v Northern Iowa | L | 23-20 |
| NCAAF | 2021/03/27 16:00 | Northern Iowa v Western Illinois | W | 34-20 |
| NCAAF | 2021/03/20 21:00 | Missouri St v Northern Iowa | L | 13-6 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | L | 16-17 |
| NCAAF | 2021/03/06 22:00 | Illinois State v Northern Iowa | W | 10-20 |
| NCAAF | 2021/02/27 17:00 | Northern Iowa v Youngstown State | W | 21-0 |