South Dakota 42-21 Western Illinois 2021-09-06 21:00
Stadium: Hanson Field Round: 1
Home Manager: Bob Nielson Away Manager: Jared Elliott
Head to Head
| NCAAF | 2019/11/02 18:00 | South Dakota v Western Illinois | L | 34-38 |
| NCAAF FCS | 2018/11/10 19:00 | Western Illinois v South Dakota | W | 12-17 |
| NCAAF | 2017/09/30 20:00 | Western Illinois v South Dakota | W | 33-38 |
Home History
| NCAAF | 2021/09/04 00:00 | South Dakota v Kansas | L | 14-17 |
| NCAAF | 2021/03/20 16:00 | South Dakota v Youngstown State | L | 10-28 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | L | 27-24 |
| NCAAF | 2021/03/04 23:00 | South Dakota v North Dakota | L | 10-21 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | W | 27-20 |
| NCAAF | 2019/11/23 20:00 | South Dakota State v South Dakota | W | 21-24 |
| NCAAF | 2019/11/16 20:30 | South Dakota v North Dakota State | L | 14-49 |
| NCAAF | 2019/11/09 20:00 | Youngstown State v South Dakota | W | 21-56 |
Away History
| NCAAF | 2021/09/02 23:00 | Western Illinois v Ball State | L | 21-31 |
| NCAAF | 2021/04/04 00:00 | Youngstown State v Western Illinois | W | 24-27 |
| NCAAF | 2021/03/27 16:00 | Northern Iowa v Western Illinois | L | 34-20 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | L | 18-26 |
| NCAAF | 2021/03/13 18:00 | North Dakota v Western Illinois | L | 38-21 |
| NCAAF | 2021/03/06 20:00 | Western Illinois v South Dakota State | L | 10-45 |
| NCAAF | 2021/02/27 18:00 | Missouri St v Western Illinois | L | 30-24 |
| NCAAF | 2019/11/23 19:00 | Western Illinois v Northern Iowa | L | 7-38 |