SE Missouri State 10-28 Murray State 2021-09-24 19:00
Stadium: Roy Stewart Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Dean Hood
Head to Head
| NCAAF | 2021/03/07 20:00 | Murray State v SE Missouri St | L | 24-21 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | W | 24-31 |
| NCAAF FCS | 2018/11/10 17:00 | SE Missouri St v Murray State | L | 38-40 |
| NCAAF | 2017/11/18 19:00 | SE Missouri St v Murray State | W | 21-10 |
Home History
| NCAAF | 2021/09/18 16:00 | SE Missouri St v Missouri | L | 28-59 |
| NCAAF | 2021/09/11 23:00 | SE Missouri St v Sam Houston State | L | 14-52 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | L | 47-21 |
| NCAAF | 2021/04/11 19:30 | SE Missouri St v Tennessee State | W | 46-23 |
| NCAAF | 2021/04/03 18:00 | SE Missouri St v Tennessee Martin | W | 21-16 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri St | W | 21-24 |
| NCAAF | 2021/03/21 19:00 | SE Missouri St v Jacksonville State | L | 3-21 |
| NCAAF | 2021/03/14 19:00 | Austin Peay v SE Missouri St | L | 49-42 |
Away History
| NCAAF | 2021/09/18 21:00 | Murray State v Bowling Green | L | 10-27 |
| NCAAF | 2021/09/11 19:30 | Murray State v Cincinnati | L | 7-42 |
| NCAAF | 2021/09/03 00:00 | Mississippi Valley State v Murray State | W | 0-35 |
| NCAAF | 2021/04/11 19:00 | Jacksonville State v Murray State | L | 28-14 |
| NCAAF | 2021/04/03 19:00 | Murray State v Austin Peay | L | 31-34 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | W | 27-41 |
| NCAAF | 2021/03/21 19:00 | Tennessee State v Murray State | W | 13-35 |
| NCAAF | 2021/03/14 18:30 | Murray State v Tennessee Tech | W | 36-31 |