SE Missouri State 10-28 Murray State 2021-10-22 17:00
Stadium: Roy Stewart Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Dean Hood
Head to Head
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/03/07 20:00 | Murray State v SE Missouri St | L | 24-21 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | W | 24-31 |
| NCAAF FCS | 2018/11/10 17:00 | SE Missouri St v Murray State | L | 38-40 |
| NCAAF | 2017/11/18 19:00 | SE Missouri St v Murray State | W | 21-10 |