[57] Syracuse 3-41 Louisville [85] 2021-09-27 15:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Dino Babers Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | L | 0-30 |
| NCAAF | 2019/11/23 21:00 | Syracuse v Louisville | L | 34-56 |
| NCAAF | 2018/11/10 00:00 | Louisville v Syracuse | W | 23-54 |
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | L | 10-56 |
| NCAAF | 2016/09/10 00:00 | Louisville v Syracuse | L | 62-28 |
| NCAAF | 2015/11/07 17:30 | Louisville v Syracuse | L | 41-17 |
| NCAAF | 2014/10/03 23:00 | Syracuse v Louisville | L | 6-28 |
| NCAAF | 2012/11/10 12:00 | Syracuse v Louisville | W | 45-26 |
Home History
| NCAAF | 2021/09/25 00:00 | Liberty v Syracuse | W | 21-24 |
| NCAAF | 2021/09/18 16:00 | Albany v Syracuse | W | 24-62 |
| NCAAF | 2021/09/11 18:00 | Rutgers v Syracuse | L | 17-7 |
| NCAAF | 2021/09/04 23:00 | Syracuse v Ohio | W | 29-9 |
| NCAAF | 2020/12/05 19:30 | Syracuse v Notre Dame | L | 21-45 |
| NCAAF | 2020/11/28 17:00 | NC State v Syracuse | L | 36-29 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | L | 0-30 |
| NCAAF | 2020/11/07 19:00 | Boston College v Syracuse | L | 16-13 |
Away History
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | W | 31-23 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |