Kentucky 52-21 Louisville 2021-09-17 18:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Mark Stoops Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2019/11/30 17:00 | Louisville v Kentucky | W | 13-45 |
| NCAAF | 2018/11/25 00:00 | Kentucky v Louisville | W | 56-10 |
| NCAAF | 2017/11/25 17:00 | Louisville v Kentucky | L | 44-17 |
| NCAAF | 2016/11/26 17:00 | Kentucky v Louisville | W | 41-38 |
| NCAAF | 2015/11/28 17:00 | Kentucky v Louisville | L | 24-38 |
| NCAAF | 2014/11/29 17:00 | Louisville v Kentucky | L | 44-40 |
| NCAAF | 2012/09/02 12:00 | Louisville v Kentucky | L | 32-14 |
| NCAAF | 2011/09/17 12:00 | Kentucky v Louisville | L | 17-24 |
Home History
| NCAAF | 2021/09/11 23:30 | Missouri v Kentucky | W | 28-35 |
| NCAAF | 2021/09/04 16:00 | UL Monroe v Kentucky | W | 10-45 |
| NCAAF | 2021/01/02 17:00 | Kentucky v NC State | W | 23-21 |
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | W | 18-41 |
| NCAAF | 2020/11/28 17:00 | Kentucky v Florida | L | 10-34 |
| NCAAF | 2020/11/21 21:00 | Kentucky v Alabama | L | 3-63 |
| NCAAF | 2020/11/14 17:00 | Vanderbilt v Kentucky | W | 35-38 |
| NCAAF | 2020/10/31 16:00 | Georgia v Kentucky | L | 14-3 |
Away History
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2020/10/31 20:00 | Virginia Tech v Louisville | L | 42-35 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |