[117] Ohio 14-49 UL Lafayette [105] 2021-09-03 16:00
Stadium: Cajun Field at Our Lady of Lourdes Stadium Round: 1
Home Manager: Tim Albin Away Manager: Billy Napier
Head to Head
| NCAAF | 2019/09/21 18:00 | Lafayette v Ohio | L | 45-25 |
| NCAAF | 2010/10/30 12:00 | Ohio v Lafayette | W | 38-31 |
| NCAAF | 2007/09/08 12:00 | Lafayette v Ohio | W | 23-31 |
Home History
| NCAAF | 2020/11/28 17:00 | Bowling Green v Ohio | W | 10-52 |
| NCAAF | 2020/11/11 00:00 | Akron v Ohio | W | 10-24 |
| NCAAF | 2020/11/05 00:00 | Ohio v Central Michigan | L | 27-30 |
| NCAAF | 2020/01/03 20:30 | Ohio v Nevada | W | 30-21 |
| NCAAF | 2019/11/26 23:00 | Ohio v Akron | W | 52-3 |
| NCAAF | 2019/11/20 00:30 | Ohio v Bowling Green | W | 66-24 |
| NCAAF | 2019/11/12 23:30 | Western Michigan v Ohio | L | 37-34 |
| NCAAF | 2019/11/07 01:00 | Miami Ohio v Ohio | L | 24-21 |
Away History
| NCAAF | 2021/04/10 16:30 | Lehigh v Lafayette | W | 13-20 |
| NCAAF | 2021/03/27 20:00 | Lafayette v Bucknell | L | 13-38 |
| NCAAF | 2021/03/13 20:30 | Colgate v Lafayette | W | 10-24 |
| NCAAF | 2020/12/26 20:30 | Lafayette v Texas-San Antonio | W | 31-24 |
| NCAAF | 2020/12/05 01:30 | Lafayette v Appalachian St | W | 24-21 |
| NCAAF | 2020/11/28 20:00 | Lafayette v UL Monroe | W | 70-20 |
| NCAAF | 2020/11/14 19:00 | South Alabama v Lafayette | W | 10-38 |
| NCAAF | 2020/11/07 17:00 | Arkansas State v Lafayette | W | 20-27 |