[89] Central Michigan 42-30 Western Michigan [49] 2021-09-18 07:00
Stadium: Waldo Stadium Round: 1
Home Manager: Jim McElwain Away Manager: Tim Lester
Head to Head
| NCAAF | 2020/11/19 00:00 | Western Michigan v Central Michigan | L | 52-44 |
| NCAAF | 2019/09/28 16:00 | Central Michigan v Western Michigan | L | 15-31 |
| NCAAF | 2018/10/20 19:00 | Western Michigan v Central Michigan | L | 35-10 |
| NCAAF | 2017/11/02 00:00 | Central Michigan v Western Michigan | W | 35-28 |
| NCAAF | 2016/10/01 23:00 | Western Michigan v Central Michigan | L | 49-10 |
| NCAAF | 2015/10/10 16:00 | Western Michigan v Central Michigan | L | 41-39 |
| NCAAF | 2014/11/22 18:00 | Central Michigan v Western Michigan | L | 20-32 |
| NCAAF | 2012/11/03 12:00 | Central Michigan v Western Michigan | L | 31-42 |
Home History
| NCAAF | 2021/09/11 19:00 | Robert Morris v Central Michigan | W | 0-45 |
| NCAAF | 2021/09/04 20:00 | Central Michigan v Missouri | L | 24-34 |
| NCAAF | 2020/12/12 20:00 | Central Michigan v Toledo | L | 23-24 |
| NCAAF | 2020/12/05 19:00 | Ball State v Central Michigan | L | 45-20 |
| NCAAF | 2020/11/27 21:00 | Central Michigan v Eastern Michigan | W | 31-23 |
| NCAAF | 2020/11/19 00:00 | Western Michigan v Central Michigan | L | 52-44 |
| NCAAF | 2020/11/12 01:00 | Central Michigan v Northern Illinois | W | 40-10 |
| NCAAF | 2020/11/05 00:00 | Ohio v Central Michigan | W | 27-30 |
Away History
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | W | 0-28 |
| NCAAF | 2021/09/04 16:00 | Western Michigan v Michigan | L | 14-47 |
| NCAAF | 2020/12/12 17:00 | Western Michigan v Ball State | L | 27-30 |
| NCAAF | 2020/12/05 19:00 | Eastern Michigan v Western Michigan | L | 53-42 |
| NCAAF | 2020/11/28 17:00 | Northern Illinois v Western Michigan | W | 27-30 |
| NCAAF | 2020/11/19 00:00 | Western Michigan v Central Michigan | W | 52-44 |
| NCAAF | 2020/11/12 01:00 | Toledo v Western Michigan | W | 38-41 |
| NCAAF | 2020/11/04 23:00 | Western Michigan v Akron | W | 58-13 |