Murray State 20-13 Eastern Illinois 2021-07-10 20:00
Stadium: O'Brien Stadium Round: 1
Home Manager: Dean Hood Away Manager: Adam Cushing
Head to Head
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | W | 27-41 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | W | 17-24 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | W | 48-41 |
| NCAAF | 2017/10/14 20:00 | Murray State v Eastern Illinois | L | 24-27 |
Home History
| NCAAF | 2021/04/11 19:00 | Jacksonville State v Murray State | L | 28-14 |
| NCAAF | 2021/04/03 19:00 | Murray State v Austin Peay | L | 31-34 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | W | 27-41 |
| NCAAF | 2021/03/21 19:00 | Tennessee State v Murray State | W | 13-35 |
| NCAAF | 2021/03/14 18:30 | Murray State v Tennessee Tech | W | 36-31 |
| NCAAF | 2021/03/07 20:00 | Murray State v SE Missouri St | W | 24-21 |
| NCAAF | 2021/02/28 20:00 | Tennessee Martin v Murray State | W | 10-14 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | L | 24-31 |
Away History
| NCAAF | 2021/04/03 18:00 | Jacksonville State v Eastern Illinois | L | 44-23 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | W | 20-28 |
| NCAAF | 2021/03/14 18:00 | Eastern Illinois v Tennessee State | L | 20-21 |
| NCAAF | 2021/03/07 19:00 | Eastern Illinois v Tennessee Martin | L | 15-28 |
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | L | 7-47 |
| NCAAF | 2019/11/23 20:00 | Eastern Illinois v Austin Peay | L | 7-35 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | L | 26-12 |