Mercer 35-38 East Tennessee State 2021-09-28 20:00
Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: Randy Sanders Away Manager: Drew Cronic
Head to Head
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | W | 13-21 |
| NCAAF | 2019/11/16 18:00 | Mercer v East Tennessee State | L | 33-38 |
| NCAAF FCS | 2018/11/03 19:00 | East Tennessee State v Mercer | L | 21-18 |
| NCAAF | 2017/09/23 19:30 | East Tennessee State v Mercer | L | 26-23 |
Home History
| NCAAF | 2021/09/25 18:00 | Mercer v Furman | W | 24-3 |
| NCAAF | 2021/09/11 20:00 | Mercer v Alabama | L | 14-48 |
| NCAAF | 2021/09/02 23:00 | Mercer v Point University Skyhawks | W | 69-0 |
| NCAAF | 2021/04/17 17:00 | Mercer v Samford | L | 20-44 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | W | 13-21 |
| NCAAF | 2021/04/03 19:30 | Furman v Mercer | W | 14-26 |
| NCAAF | 2021/03/27 16:00 | Mercer v Tennessee Chattanooga | W | 35-28 |
| NCAAF | 2021/03/20 20:00 | Mercer v Western Carolina | W | 45-28 |
Away History
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford | W | 55-48 |
| NCAAF | 2021/09/18 23:30 | Delaware State v East Tennessee State | W | 6-38 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | W | 45-14 |
| NCAAF | 2021/09/05 00:00 | East Tennessee State v Vanderbilt | W | 23-3 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | L | 13-21 |
| NCAAF | 2021/04/03 17:30 | East Tennessee State v VMI | W | 24-20 |
| NCAAF | 2021/03/27 17:00 | Western Carolina v East Tennessee State | W | 17-24 |
| NCAAF | 2021/03/20 17:00 | East Tennessee State v The Citadel | W | 28-21 |