[15] Leyton Orient 0-1 Colchester [21] 2021-11-27 05:00
Stadium: Matchroom Stadium Round: 30
Referee: Tom Reeves Home Manager: Kenneth Francis Jackett Away Manager: Wayne Brown
Head to Head
| England League 2 | 2021/02/06 15:00 | Leyton Orient v Colchester | D | 0-0 |
| England League 2 | 2020/11/14 15:00 | Colchester v Leyton Orient | L | 2-1 |
| England League 2 | 2019/12/26 13:00 | Leyton Orient v Colchester | L | 1-3 |
| England League 2 | 2019/09/21 14:00 | Colchester v Leyton Orient | L | 2-1 |
| England League 2 | 2017/04/29 14:00 | Leyton Orient v Colchester | L | 1-3 |
| England League 2 | 2016/11/12 15:00 | Colchester v Leyton Orient | W | 0-3 |
| Club Friendly List | 2015/07/25 14:00 | Colchester v Leyton Orient | W | 0-3 |
| England League 1 | 2015/01/24 15:00 | Colchester v Leyton Orient | L | 2-0 |
Home History
| England League 2 | 2021/11/23 19:45 | Scunthorpe v Leyton Orient | D | 1-1 |
| England League 2 | 2021/11/20 15:00 | Leyton Orient v Sutton Utd | W | 4-1 |
| England League 2 | 2021/11/13 15:00 | Rochdale v Leyton Orient | D | 2-2 |
| England EFL Trophy | 2021/11/09 19:00 | Leyton Orient v Charlton | W | 1-0 |
| England FA Cup | 2021/11/06 15:00 | Leyton Orient v Ebbsfleet United | W | 1-0 |
| England League 2 | 2021/10/30 14:00 | Leyton Orient v Hartlepool | W | 5-0 |
| England League 2 | 2021/10/23 14:00 | Stevenage v Leyton Orient | D | 0-0 |
| England League 2 | 2021/10/19 18:45 | Leyton Orient v Forest Green | D | 1-1 |
Away History
| England League 2 | 2021/11/26 19:45 | Colchester v Newport County | D | 1-1 |
| England League 2 | 2021/11/23 19:45 | Colchester v Exeter | W | 3-1 |
| England League 2 | 2021/11/20 15:00 | Stevenage v Colchester | L | 1-0 |
| England EFL Trophy | 2021/11/09 19:45 | Ipswich v Colchester | D | 0-0 |
| England FA Cup | 2021/11/05 19:55 | AFC Sudbury v Colchester | W | 0-4 |
| England League 2 | 2021/10/30 14:00 | Colchester v Scunthorpe | W | 2-1 |
| England League 2 | 2021/10/26 18:45 | Colchester v Sutton Utd | L | 1-3 |
| England League 2 | 2021/10/23 14:00 | Port Vale v Colchester | L | 3-0 |