[4] DET Red Wings 2-6 STL Blues [3] 2021-08-25 09:00
Stadium: Enterprise Center
Home Manager: Craig Berube Away Manager: Jeff Blashill
Head to Head
| NHL | 2019/10/27 21:00 | STL Blues v DET Red Wings | L | 5-4 |
| NHL Pre-Season | 2019/09/26 23:00 | STL Blues v DET Red Wings | W | 1-4 |
| NHL | 2019/03/22 00:00 | DET Red Wings v STL Blues | L | 2-5 |
| NHL | 2018/11/29 00:00 | STL Blues v DET Red Wings | W | 3-4 |
| NHL | 2018/03/01 01:00 | DET Red Wings v STL Blues | L | 1-2 |
| NHL | 2017/12/09 18:00 | STL Blues v DET Red Wings | L | 6-1 |
| NHL | 2017/02/16 01:00 | STL Blues v DET Red Wings | L | 2-0 |
| NHL | 2016/10/28 00:00 | DET Red Wings v STL Blues | W | 2-1 |
Home History
| NHL | 2021/05/08 23:00 | DET Red Wings v CLB Blue Jackets | L | 4-5 |
| NHL | 2021/05/07 23:00 | DET Red Wings v CLB Blue Jackets | W | 5-2 |
| NHL | 2021/05/02 19:00 | TB Lightning v DET Red Wings | L | 2-1 |
| NHL | 2021/05/01 19:00 | TB Lightning v DET Red Wings | W | 0-1 |
| NHL | 2021/04/29 23:00 | DET Red Wings v CAR Hurricanes | L | 1-3 |
| NHL | 2021/04/27 23:00 | DET Red Wings v CLB Blue Jackets | L | 0-1 |
| NHL | 2021/04/24 23:00 | DAL Stars v DET Red Wings | L | 2-1 |
| NHL | 2021/04/22 23:30 | DAL Stars v DET Red Wings | W | 3-7 |
Away History
| NHL | 2021/05/23 21:00 | COL Avalanche v STL Blues | L | 5-2 |
| NHL | 2021/05/22 01:30 | COL Avalanche v STL Blues | L | 5-1 |
| NHL | 2021/05/20 02:30 | STL Blues v COL Avalanche | L | 3-6 |
| NHL | 2021/05/18 02:00 | STL Blues v COL Avalanche | L | 1-4 |
| NHL | 2021/05/14 00:00 | MIN Wild v STL Blues | W | 3-7 |
| NHL | 2021/05/13 01:00 | MIN Wild v STL Blues | W | 0-4 |
| NHL | 2021/05/11 02:00 | STL Blues v LA Kings | W | 2-1 |
| NHL | 2021/05/09 02:00 | STL Blues v VGS Golden Knights | L | 1-4 |