[6] BUF Sabres 1-4 NY Islanders [14] 2021-10-13 06:30
Stadium: UBS Arena
Home Manager: Don Granato Away Manager: Barry Trotz
Head to Head
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | W | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | W | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | L | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-1 |
Home History
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | W | 5-4 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
Away History
| NHL Pre-Season | 2021/10/09 23:00 | NY Rangers v NY Islanders | L | 5-4 |
| NHL Pre-Season | 2021/10/05 23:00 | PHI Flyers v NY Islanders | W | 0-3 |
| NHL Pre-Season | 2021/10/02 18:00 | NJ Devils v NY Islanders | L | 2-1 |
| NHL Pre-Season | 2021/09/28 23:00 | NY Islanders v PHI Flyers | W | 3-2 |
| NHL Pre-Season | 2021/09/26 23:00 | NY Islanders v NY Rangers | W | 4-0 |
| NHL | 2021/06/26 00:00 | NY Islanders v TB Lightning | L | 0-1 |
| NHL | 2021/06/24 00:00 | TB Lightning v NY Islanders | W | 2-3 |
| NHL | 2021/06/22 00:00 | NY Islanders v TB Lightning | L | 0-8 |