[52] Clemson 30-24 Louisville [81] 2021-08-19 19:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2019/10/19 16:00 | Clemson v Louisville | W | 45-10 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | W | 16-77 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | W | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | W | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | W | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | W | 23-17 |
Home History
| NCAAF | 2021/01/02 01:00 | Ohio State v Clemson | L | 49-28 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | W | 34-10 |
| NCAAF | 2020/12/06 00:30 | Clemson v Virginia Tech | W | 45-10 |
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | W | 17-52 |
| NCAAF | 2020/11/08 00:30 | Clemson v Notre Dame | L | 40-47 |
| NCAAF | 2020/10/31 16:00 | Boston College v Clemson | W | 28-34 |
| NCAAF | 2020/10/24 16:00 | Syracuse v Clemson | W | 21-47 |
| NCAAF | 2020/10/17 16:00 | Clemson v Georgia Tech | W | 73-7 |
Away History
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2020/10/31 20:00 | Virginia Tech v Louisville | L | 42-35 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |
| NCAAF | 2020/10/17 18:30 | Louisville v Notre Dame | L | 7-12 |
| NCAAF | 2020/10/09 23:00 | Louisville v Georgia Tech | L | 27-46 |