Stadium: Carver-Hawkeye Arena
Home Manager: Austin Parkinson Away Manager: Lisa Bluder
| WNCAAB | 2021/12/09 00:00 | Ball State (W) v IUPUI (W) | L | 73-67 |
| WNCAAB | 2021/12/04 19:00 | IUPUI (W) v Oakland (W) | W | 74-49 |
| WNCAAB | 2021/12/03 00:00 | IUPUI (W) v Detroit Women | W | 87-52 |
| WNCAAB | 2021/11/28 20:00 | Butler (W) v IUPUI (W) | W | 47-80 |
| WNCAAB | 2021/11/14 19:00 | IUPUI (W) v Bowling Green (W) | W | 71-60 |
| WNCAAB | 2021/11/10 00:00 | IUPUI (W) v Michigan (W) | L | 62-67 |
| WNCAAB | 2021/03/09 17:00 | IUPUI (W) v Wright State (W) | L | 41-53 |
| WNCAAB | 2021/03/08 19:00 | IUPUI (W) v Wisc Milwaukee (W) | W | 56-46 |
| WNCAAB | 2021/12/09 00:00 | Iowa (W) v Iowa State (W) | L | 70-77 |
| WNCAAB | 2021/12/05 21:00 | Michigan State (W) v Iowa (W) | W | 61-88 |
| WNCAAB | 2021/12/03 02:00 | Iowa (W) v Duke (W) | L | 64-79 |
| WNCAAB | 2021/11/18 00:30 | Southern (W) v Iowa (W) | W | 67-87 |
| WNCAAB | 2021/11/14 20:00 | Iowa (W) v Northern Iowa (W) | W | 82-61 |
| WNCAAB | 2021/11/12 00:30 | Samford (W) v Iowa (W) | W | 54-91 |
| WNCAAB | 2021/11/10 00:00 | New Hampshire (W) v Iowa (W) | W | 50-93 |
| WNCAAB | 2021/03/27 17:00 | Iowa (W) v Connecticut (W) | L | 72-92 |