Stadium: CEFCU Arena
Home Manager: Kate Achter Away Manager: Kristen Gillespie
| WNCAAB | 2021/03/13 02:00 | Loyola Chicago (W) v Illinois State (W) | W | 61-60 |
| WNCAAB | 2021/03/06 21:00 | Illinois State (W) v Loyola Chicago (W) | L | 60-45 |
| WNCAAB | 2021/03/05 21:00 | Illinois State (W) v Loyola Chicago (W) | L | 64-61 |
| WNCAAB | 2020/02/15 01:00 | Illinois State (W) v Loyola Chicago (W) | L | 86-85 |
| WNCAAB | 2020/01/19 19:00 | Illinois State (W) v Loyola Chicago (W) | W | 64-69 |
| WNCAAB | 2019/03/01 01:30 | Illinois State (W) v Loyola Chicago (W) | L | 65-52 |
| WNCAAB | 2019/02/02 01:00 | Illinois State (W) v Loyola Chicago (W) | W | 59-62 |
| WNCAAB | 2018/02/03 01:00 | Illinois State (W) v Loyola Chicago (W) | L | 57-49 |
| WNCAAB | 2021/12/11 18:00 | Loyola Chicago (W) v Central Michigan (W) | W | 69-48 |
| WNCAAB | 2021/12/09 01:00 | Eastern Illinois (W) v Loyola Chicago (W) | W | 48-58 |
| WNCAAB | 2021/12/05 17:00 | Loyola Chicago (W) v Vermont (W) | L | 62-72 |
| WNCAAB | 2021/12/04 00:00 | Loyola Chicago (W) v Dartmouth (W) | W | 73-37 |
| WNCAAB | 2021/11/28 19:00 | Miami Ohio (W) v Loyola Chicago (W) | W | 52-69 |
| WNCAAB | 2021/11/24 19:00 | Loyola Chicago (W) v St. Francis (IL) Women | W | 96-61 |
| WNCAAB | 2021/11/20 18:00 | Chicago State (W) v Loyola Chicago (W) | W | 59-71 |
| WNCAAB | 2021/11/18 01:00 | Loyola Chicago (W) v Northwestern (W) | L | 47-63 |
| WNCAAB | 2021/12/11 19:00 | Illinois State (W) v SIU Edwardsville (W) | W | 80-71 |
| WNCAAB | 2021/12/05 20:00 | Dayton (W) v Illinois State (W) | L | 78-67 |
| WNCAAB | 2021/12/01 16:00 | Illinois State (W) v Missouri Baptist Women | W | 91-42 |
| WNCAAB | 2021/11/27 19:30 | Illinois State (W) v Sacramento State (W) | L | 63-65 |
| WNCAAB | 2021/11/26 22:30 | Illinois State (W) v UC Irvine (W) | L | 55-67 |
| WNCAAB | 2021/11/20 20:00 | Illinois State (W) v Tennessee Martin (W) | L | 52-54 |
| WNCAAB | 2021/11/18 00:00 | Purdue (W) v Illinois State (W) | L | 76-64 |
| WNCAAB | 2021/11/13 19:00 | Illinois State (W) v St. Thomas (MN) (W) | W | 70-55 |