Stadium: Knapp Center
Home Manager: Bryan Mullins Away Manager: Darian DeVries
| NCAAB | 2021/01/05 00:00 | Southern Illinois v Drake | L | 55-86 |
| NCAAB | 2021/01/03 23:00 | Southern Illinois v Drake | L | 55-73 |
| NCAAB | 2020/02/01 23:00 | Southern Illinois v Drake | W | 79-72 |
| NCAAB | 2020/01/19 21:00 | Drake v Southern Illinois | W | 49-66 |
| NCAAB | 2019/02/13 01:00 | Drake v Southern Illinois | L | 72-69 |
| NCAAB | 2019/01/09 01:00 | Southern Illinois v Drake | L | 70-82 |
| NCAAB | 2018/01/31 01:00 | Southern Illinois v Drake | W | 78-67 |
| NCAAB | 2017/12/31 21:00 | Drake v Southern Illinois | L | 70-67 |
| NCAAB | 2021/12/22 22:00 | Southern Illinois v San Francisco | L | 52-64 |
| NCAAB | 2021/12/18 21:00 | Southern Illinois v Maryville | W | 75-55 |
| NCAAB | 2021/12/16 01:00 | SE Missouri State v Southern Illinois | W | 55-80 |
| NCAAB | 2021/12/11 19:00 | Southern Illinois v Tulsa | L | 65-69 |
| NCAAB | 2021/12/05 02:00 | Southern Miss v Southern Illinois | W | 41-66 |
| NCAAB | 2021/12/02 00:00 | Southern Illinois v Evansville | W | 54-52 |
| NCAAB | 2021/11/27 01:00 | Alcorn State v Southern Illinois | W | 59-62 |
| NCAAB | 2021/11/22 22:45 | Creighton v Southern Illinois | L | 66-64 |
| NCAAB | 2021/12/22 23:00 | Chicago St v Drake | W | 50-87 |
| NCAAB | 2021/12/19 20:00 | Tennessee Martin v Drake | W | 54-80 |
| NCAAB | 2021/12/17 01:00 | Jackson State v Drake | W | 65-70 |
| NCAAB | 2021/12/11 19:00 | Drake v Clemson | L | 80-90 |
| NCAAB | 2021/12/09 02:00 | Drake v Nebraska Omaha | W | 78-70 |
| NCAAB | 2021/12/05 20:00 | St. Thomas (MN) v Drake | W | 64-74 |
| NCAAB | 2021/12/03 02:00 | Valparaiso v Drake | W | 66-73 |
| NCAAB | 2021/11/28 15:30 | North Texas v Drake | L | 57-54 |