Southern Illinois 22-10 South Dakota 2021-08-08 07:00
Stadium: DakotaDome Round: 1
Home Manager: Nick Hill Away Manager: Bob Nielson
Head to Head
| NCAAF | 2019/10/26 21:00 | SO Illinois v South Dakota | W | 48-28 |
| NCAAF | 2018/09/29 23:00 | South Dakota v SO Illinois | L | 31-24 |
| NCAAF | 2017/10/28 20:00 | South Dakota v SO Illinois | L | 42-0 |
Home History
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/04/24 20:00 | SO Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | W | 48-55 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | W | 16-17 |
| NCAAF | 2021/03/06 17:00 | SO Illinois v Youngstown State | W | 30-22 |
| NCAAF | 2021/02/27 18:00 | North Dakota State v SO Illinois | W | 14-38 |
Away History
| NCAAF | 2021/03/20 16:00 | South Dakota v Youngstown State | L | 10-28 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | L | 27-24 |
| NCAAF | 2021/03/04 23:00 | South Dakota v North Dakota | L | 10-21 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | W | 27-20 |
| NCAAF | 2019/11/23 20:00 | South Dakota State v South Dakota | W | 21-24 |
| NCAAF | 2019/11/16 20:30 | South Dakota v North Dakota State | L | 14-49 |
| NCAAF | 2019/11/09 20:00 | Youngstown State v South Dakota | W | 21-56 |
| NCAAF | 2019/11/02 18:00 | South Dakota v Western Illinois | L | 34-38 |