Stadium: Gentry Complex
Home Manager: Sean Woods Away Manager: Brian Collins
| NCAAB | 2021/03/12 02:30 | Southern v Grambling State | L | 67-72 |
| NCAAB | 2021/03/06 21:00 | Southern v Texas Southern | L | 74-80 |
| NCAAB | 2021/03/05 01:30 | Southern v Prairie View | L | 61-68 |
| NCAAB | 2021/02/27 22:30 | Alcorn State v Southern | W | 75-89 |
| NCAAB | 2021/02/24 20:30 | Alabama A&M v Southern | W | 57-73 |
| NCAAB | 2021/02/23 01:30 | Alabama State v Southern | W | 66-75 |
| NCAAB | 2021/02/13 19:45 | Southern v Arkansas-Pine Bluff | W | 73-71 |
| NCAAB | 2021/02/09 02:00 | Jackson State v Southern | L | 57-53 |
| NCAAB | 2021/02/28 00:00 | Tennessee State v Eastern Kentucky | L | 84-89 |
| NCAAB | 2021/02/26 00:00 | Tennessee State v Morehead State | L | 60-74 |
| NCAAB | 2021/02/20 22:00 | Jacksonville St v Tennessee State | L | 77-76 |
| NCAAB | 2021/02/19 02:00 | Tennessee Tech v Tennessee State | W | 86-91 |
| NCAAB | 2021/02/13 22:00 | Eastern Kentucky v Tennessee State | L | 93-73 |
| NCAAB | 2021/02/12 02:00 | Morehead State v Tennessee State | L | 79-66 |
| NCAAB | 2021/02/06 22:00 | Tennessee State v Eastern Illinois | L | 72-86 |
| NCAAB | 2021/02/04 19:00 | Tennessee State v SIU Edwardsville | L | 60-68 |