Houston 20-35 Cincinnati 2021-10-30 21:00
Stadium: Nippert Stadium Round: 1
Home Manager: Luke Fickell Away Manager: Dana Holgorsen
Head to Head
| NCAAF | 2020/11/07 20:30 | Houston v Cincinnati | L | 10-38 |
| NCAAF | 2019/10/12 19:30 | Cincinnati v Houston | L | 38-23 |
| NCAAF | 2016/09/15 23:30 | Houston v Cincinnati | W | 40-16 |
| NCAAF | 2015/11/07 20:30 | Houston v Cincinnati | W | 33-30 |
| NCAAF | 2014/12/06 17:00 | Cincinnati v Houston | L | 38-31 |
| NCAAF | 2002/11/16 12:00 | Cincinnati v Houston | L | 47-14 |
| NCAAF | 2001/10/20 12:00 | Houston v Cincinnati | L | 28-29 |
| NCAAF | 2000/10/07 12:00 | Cincinnati v Houston | L | 48-31 |
Home History
| NCAAF | 2021/10/24 01:20 | East Carolina v Houston | W | 24-31 |
| NCAAF | 2021/10/07 23:30 | Houston v Tulane | W | 40-22 |
| NCAAF | 2021/10/01 23:30 | Houston v Tulsa | W | 45-10 |
| NCAAF | 2021/09/25 23:00 | Navy v Houston | W | 20-28 |
| NCAAF | 2021/09/18 23:00 | Grambling State v Houston | W | 0-45 |
| NCAAF | 2021/09/11 22:30 | Houston v Rice | W | 44-7 |
| NCAAF | 2021/09/04 23:00 | Texas Tech v Houston | L | 38-21 |
| NCAAF | 2020/12/24 20:30 | Hawaii v Houston | L | 28-14 |
Away History
| NCAAF | 2021/10/30 16:00 | Cincinnati v Tulane | W | 31-12 |
| NCAAF | 2021/10/23 16:00 | Cincinnati v Navy | W | 27-20 |
| NCAAF | 2021/10/16 16:00 | Central Florida v Cincinnati | W | 21-56 |
| NCAAF | 2021/10/08 23:00 | Temple v Cincinnati | W | 3-52 |
| NCAAF | 2021/10/02 18:30 | Cincinnati v Notre Dame | W | 24-13 |
| NCAAF | 2021/09/18 16:00 | Cincinnati v Indiana | W | 38-24 |
| NCAAF | 2021/09/11 19:30 | Murray State v Cincinnati | W | 7-42 |
| NCAAF | 2021/09/04 19:30 | Miami Ohio v Cincinnati | W | 14-49 |