Stadium: Gerald J. Ford Stadium Round: 326
Home Manager: Scott Satterfield Away Manager: Troy Calhoun
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | L | 34-37 |
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | W | 31-23 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2021/10/09 23:00 | Wyoming v Air Force | W | 14-24 |
| NCAAF | 2021/10/02 22:30 | Air Force v New Mexico | W | 38-10 |
| NCAAF | 2021/09/26 00:00 | Florida Atlantic v Air Force | W | 7-31 |
| NCAAF | 2021/09/18 23:30 | Utah State v Air Force | L | 49-45 |
| NCAAF | 2021/09/11 19:30 | Air Force v Navy | W | 23-3 |
| NCAAF | 2021/09/04 18:00 | Lafayette v Air Force | W | 14-35 |
| NCAAF | 2020/12/19 20:00 | Air Force v Army | L | 7-10 |
| NCAAF | 2020/12/04 02:30 | Air Force v Utah State | W | 35-7 |