[5] Cruz Azul 0-1 Atletico San Luis [10] 2021-12-10 12:00
Stadium: Estadio Azteca Round: 16
Referee: Jesus Rafael Lopez Valle Home Manager: Juan Reynoso Away Manager: Andre Jardine
Head to Head
| Mexico Liga MX | 2021/08/22 02:00 | Atletico San Luis v Cruz Azul | D | 0-0 |
| Mexico Liga MX | 2021/04/24 22:00 | Cruz Azul v Atletico San Luis | W | 3-2 |
| Mexico Liga MX | 2020/08/24 00:35 | Atletico San Luis v Cruz Azul | W | 1-3 |
| Mexico Liga MX | 2020/01/18 01:00 | Atletico San Luis v Cruz Azul | L | 2-1 |
| Mexico Liga MX | 2019/11/24 01:00 | Cruz Azul v Atletico San Luis | W | 3-1 |
Home History
| Mexico Liga MX | 2021/11/22 01:15 | Cruz Azul v Monterrey | L | 1-4 |
| Mexico Liga MX | 2021/11/07 23:00 | Unam Pumas v Cruz Azul | L | 4-3 |
| Mexico Liga MX | 2021/11/04 03:00 | Cruz Azul v Leon | L | 0-1 |
| Mexico Liga MX | 2021/10/31 23:05 | Cruz Azul v Club America | W | 2-1 |
| Mexico Liga MX | 2021/10/24 02:00 | Chivas Guadalajara v Cruz Azul | D | 1-1 |
| Mexico Liga MX | 2021/10/20 02:05 | Atlas v Cruz Azul | D | 0-0 |
| Mexico Liga MX | 2021/10/17 02:00 | Cruz Azul v Tigres UANL | D | 1-1 |
| Mexico Liga MX | 2021/10/04 02:06 | Tijuana v Cruz Azul | W | 0-1 |
Away History
| Mexico Liga MX | 2021/11/21 01:00 | Santos Laguna v Atletico San Luis | L | 2-0 |
| Mexico Liga MX | 2021/11/08 01:06 | Santos Laguna v Atletico San Luis | D | 0-0 |
| Mexico Liga MX | 2021/11/04 01:00 | Pachuca v Atletico San Luis | D | 0-0 |
| Mexico Liga MX | 2021/11/01 01:05 | Atletico San Luis v Monterrey | D | 1-1 |
| Mexico Liga MX | 2021/10/25 00:00 | Atletico San Luis v Atlas | L | 2-6 |
| Mexico Liga MX | 2021/10/17 00:00 | Atletico San Luis v Club America | L | 0-1 |
| Mexico Liga MX | 2021/10/02 22:00 | Leon v Atletico San Luis | D | 0-0 |
| Mexico Liga MX | 2021/09/29 22:00 | Atletico San Luis v Tigres UANL | L | 0-3 |