[5] Cruz Azul 0-1 Atletico San Luis [10] 2022-02-26 10:00
Stadium: Estadio Azteca Round: 16
Referee: Jesus Rafael Lopez Valle Home Manager: Juan Reynoso Away Manager: Andre Jardine
Head to Head
| Mexico Liga MX | 2021/08/22 02:00 | Atletico San Luis v Cruz Azul | D | 0-0 |
| Mexico Liga MX | 2021/04/24 22:00 | Cruz Azul v Atletico San Luis | W | 3-2 |
| Mexico Liga MX | 2020/08/24 00:35 | Atletico San Luis v Cruz Azul | W | 1-3 |
| Mexico Liga MX | 2020/01/18 01:00 | Atletico San Luis v Cruz Azul | L | 2-1 |
| Mexico Liga MX | 2019/11/24 01:00 | Cruz Azul v Atletico San Luis | W | 3-1 |
Home History
| CONCACAF Champions Cup | 2022/02/25 01:30 | Cruz Azul v Forge FC | W | 3-1 |
| Mexico Liga MX | 2022/02/21 00:00 | Toluca v Cruz Azul | W | 1-4 |
| CONCACAF Champions Cup | 2022/02/17 01:00 | Forge FC v Cruz Azul | W | 0-1 |
| Mexico Liga MX | 2022/02/13 01:00 | Cruz Azul v Necaxa | L | 1-2 |
| Mexico Liga MX | 2022/02/08 03:05 | Leon v Cruz Azul | W | 0-1 |
| Mexico Liga MX | 2022/01/23 03:06 | Monterrey v Cruz Azul | D | 2-2 |
| Mexico Liga MX | 2022/01/16 03:00 | Cruz Azul v Juarez FC | W | 1-0 |
| Mexico Liga MX | 2022/01/09 03:00 | Cruz Azul v Tijuana | W | 2-0 |
Away History
| Mexico Liga MX | 2022/02/20 01:00 | Tigres UANL v Atletico San Luis | L | 2-1 |
| Mexico Liga MX | 2022/02/12 23:00 | Atletico San Luis v Toluca | L | 0-1 |
| Mexico Liga MX | 2022/02/06 01:00 | Club America v Atletico San Luis | W | 2-3 |
| Mexico Liga MX | 2022/01/21 03:00 | Atletico San Luis v Juarez FC | L | 0-1 |
| Mexico Liga MX | 2022/01/15 23:00 | Atlas v Atletico San Luis | L | 1-0 |
| Mexico Liga MX | 2022/01/07 03:00 | Atletico San Luis v Pachuca | L | 0-2 |
| World Club Friendlies | 2021/12/23 23:00 | Atletico San Luis v Necaxa | W | 3-1 |
| Mexico Liga MX | 2021/11/21 01:00 | Santos Laguna v Atletico San Luis | L | 2-0 |