Stadium: Audi Field
Referee: Rubiel Vazquez Home Manager: Away Manager: Ezra Hendrickson
| USA MLS | 2021/09/15 23:30 | DC United v Chicago Fire | W | 3-0 |
| USA MLS | 2021/07/22 00:00 | Chicago Fire v DC United | D | 2-2 |
| USA MLS | 2021/05/14 00:00 | DC United v Chicago Fire | W | 1-0 |
| USA MLS | 2020/10/11 23:30 | Chicago Fire v DC United | L | 2-1 |
| USA MLS | 2019/07/28 00:00 | Chicago Fire v DC United | D | 0-0 |
| USA MLS | 2019/05/30 00:00 | DC United v Chicago Fire | D | 3-3 |
| USA MLS | 2018/10/28 20:30 | Chicago Fire v DC United | D | 0-0 |
| USA MLS | 2018/10/07 17:00 | DC United v Chicago Fire | W | 2-1 |
| USA MLS | 2021/11/07 20:30 | Toronto FC v DC United | W | 1-3 |
| USA MLS | 2021/10/30 23:30 | DC United v Columbus Crew | L | 1-3 |
| USA MLS | 2021/10/27 23:30 | DC United v New York Red Bulls | W | 1-0 |
| USA MLS | 2021/10/23 23:30 | New York City FC v DC United | L | 6-0 |
| USA MLS | 2021/10/20 23:30 | DC United v New England Revolution | L | 2-3 |
| USA MLS | 2021/10/16 23:30 | DC United v Nashville SC | D | 0-0 |
| USA MLS | 2021/10/02 23:30 | Orlando City SC v DC United | L | 2-1 |
| USA MLS | 2021/09/29 23:30 | DC United v Minnesota United | W | 3-1 |
| USA MLS | 2021/11/07 20:30 | Columbus Crew v Chicago Fire | L | 2-0 |
| USA MLS | 2021/10/27 23:30 | New York City FC v Chicago Fire | L | 1-0 |
| USA MLS | 2021/10/24 00:00 | Chicago Fire v Real Salt Lake | W | 1-0 |
| USA MLS | 2021/10/20 23:30 | FC Cincinnati v Chicago Fire | W | 3-4 |
| USA MLS | 2021/10/16 23:00 | New England Revolution v Chicago Fire | D | 2-2 |
| USA MLS | 2021/10/03 20:00 | Toronto FC v Chicago Fire | L | 3-1 |
| USA MLS | 2021/09/30 00:00 | Chicago Fire v New York City FC | W | 2-0 |
| USA MLS | 2021/09/26 17:00 | Chicago Fire v Nashville SC | D | 0-0 |